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Daisy


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Lung Cancer Patients Live Longer with Drug Targeting T cells

Feb 24, 2016 1:00:46 PM / by Daisy posted in clinical trial, PD-1, PD-L1, pembrolizumab, Immunotherapy (Immunology)

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Pembrolizumab, a newer drug, harnesses T cells to tackle cancer. For certain lung cancer patients, this means having twice the lifespan than that accorded by chemotherapy! 

For patients battling lung cancer, the majority are of the non-small-cell lung carcinoma (NSCLC) subtype. Among these, a subgroup of tumors produce a protein, PD-L1, which enables escape from attack by the patient’s immune system (see here). Specifically, PD-L1 binds to PD-1 receptors on T cells, thereby preventing T cells from activating, proliferating, and/or producing cytokines, so that T cells do not mount an attack towards the PD-L1-positive tumor cells.

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Developing Antibody Drugs Against B-cells

Jan 11, 2016 1:00:44 PM / by Daisy posted in Cancer, clinical trial, obinutuzumab, Basic Research, Immunotherapy (Immunology)

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The success of rituximab as an antibody drug targeting B-cells has led to the development of obinutuzumab – a similar, third-generation drug

Chronic lymphocytic leukemia (CLL) is a B-cell disease that is currently incurable. Combining targeted drugs has improved overall survival. However, not all patients benefit, because B-cells can harness any of several mechanisms to gain unrestricted proliferative capacity (see here).

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Curing Babies before Birth with Stem Cell Transplantation

Dec 16, 2015 1:00:14 PM / by Daisy posted in Stem Cell Therapy, Stem Cells, Basic Research

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A clinical trial will for the first time evaluate stem cell transplantation in unborn babies as curative therapy for osteogenesis imperfecta

It is estimated that 30,000 individuals in the US live with osteogenesis imperfecta (OI). Tagged as “brittle bone disease”, OI is caused by deficiencies in the skeleton building block, collagen. There is no cure; treatment consists of procedures to increase bone strength and mobility.

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Learning from Stem Cells Modeling Leukemia in a Dish

Nov 9, 2015 1:00:57 PM / by Daisy posted in leukemia, Stem Cells, Basic Research

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Researchers use skin cells from pediatric patients and program them into stem cells to investigate molecular mechanisms for rare form of childhood leukemia

Juvenile myelomonocytic leukemia (JMML) is diagnosed in children whose average age at diagnosis is two. Hematopoietic stem cell transplantation can cure some patients but not all. On the other end, minimal treatment -- or none at all -- can also result in remission. How does one decide how to treat JMML patients?

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CAR T Cells, Little Steps, Huge Progress

Oct 14, 2015 1:00:51 PM / by Daisy posted in CAR-T, clinical trial, leukemia, Basic Research, Immunotherapy (Immunology)

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Therapeutic CAR T cells administered to leukemia patients in a clinical trial offer long remissions associated with T cells that persist out to at least 4 years

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