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Dalia Gaddis


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A New Therapy Against Tuberculosis: NOD-2 Derived Dendritic Cells

Jul 27, 2016 1:00:57 PM / by Dalia Gaddis posted in Bone Marrow, Dendritic Cells, T Cells, Basic Research

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Scientists find that NOD-2 derived dendritic cells have superior bactericidal activity.

Intracellular bacterial infections, such as tuberculosis, Listeria or E. coli, are serious health threats. All can be deadly if our immune system fails to contain and get rid of the infection promptly. Scientists have just found a way to make dendritic cells better at restricting the growth of intracellular bacteria, particularly tuberculosis.

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Cord Blood Regulatory T cells Provide New Hope for Transplant Patients

Jul 20, 2016 1:00:08 PM / by Dalia Gaddis posted in Cord Blood, Regulatory T Cells

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A clinical trial shows that cord blood regulatory T cells help reduce GVHD in high-risk blood malignancies.

One of the worst adverse effects of bone marrow or stem cell transplant is graft versus host disease. Side effects can range from rashes to a complete destruction of vital organs such as kidneys or liver. Thanks to regulatory T cells from cord blood, transplant patients may have a better therapy option.

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Inducing Fas Ligand in Dendritic Cells Gives Them an Edge Against Inflammatory Bowl Disease

Jul 11, 2016 1:00:32 PM / by Dalia Gaddis posted in crohn's disease, Inflammation, T Cells, therapy, Basic Research

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Researchers find that dendritic cells transduced with Fas Ligand are effective in treating colon inflammation.

Dendritic cells are constantly sampling the lumen of the intestines for harmful bacterial. Once they find a threat, they migrate to the neighboring lymph nodes to activate T cells. Since our intestines contain hundreds of millions of bacterial cells, dendritic cells have developed to ignore the commensal bacteria that would not harm us. This “ignorance” or tolerance has proved essential for intestinal health. Breakdown of this tolerance results in inflammatory bowel diseases or IBD. We have previously written about how defective dendritic cells are to blame for the initiation of IBD.

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A New Method to Enrich for Osteoprogenitors in Stem Cells

Jun 27, 2016 1:00:23 PM / by Dalia Gaddis posted in Bone Marrow, Stem Cell Therapy, Stem Cells

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Scientists find that the marker CD34 may enrich for osteoprogenitors in bone marrow stem cells.

The use of stem cells for bone regeneration is an idea that scientists have been experimenting with for a few decades. In a previous blog, we highlighted new research where stem cells isolated from extracellular vesicles can help regenerate bone tissue. Here, we focus on another exciting study that may benefit bone regeneration from these cells.

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Another Advantage for Stem Cells: They Can Help Heal Foot Ulcers in Diabetic Patients

Jun 15, 2016 1:00:33 PM / by Dalia Gaddis posted in Bone Marrow, Stem Cell Therapy, Blood Disorders

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Scientists find that stem cells may be beneficial in treating diabetic patients with critical limb ischemia and foot ulcers.

Bone marrow stem cells are known for their capacity to self-renew and ability to give rise to different cell types. They can be used for tissue regeneration and treatment against different types of cancer. The extent of their benefits does not stop there. Stem cells also may help heal foot ulcers in diabetic patients.

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