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Stem Cells Have Smart Switch to Keep Their Number Under Control

Feb 15, 2016 1:00:19 PM / by Shweta posted in Regenerative Medicine, Stem Cell Therapy, Stem Cells

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The Prkci gene maintains the stem cells homeostasis in the adult body

One of the striking features of stem cells is their ability to make copies of themselves whenever it is required, a property known as 'self-renewal'. This process keeps cell division under control, which is required for continuous regeneration in the human body. It is very important to keep proliferation under check; otherwise, an excess of symmetric division can lead to teratoma formation, but also an insufficient number may inhibit the repair and maintenance of the body. In a nutshell, stem cells play a very crucial role in maintaining the homeostasis of the adult body.

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Scientists Grow Retinal Ganglion Cells from Stem Cells

Jan 27, 2016 1:00:04 PM / by Shweta posted in iPSCs, Stem Cells, Basic Research

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The gene editing tool CRISPR along with stem cells help scientists create retinal ganglion cells in the lab

Degeneration of retinal ganglion cells often leads to progressive and irreversible vision loss. These cells are the type of nerve cells located within the retina, which transmit visual signals from the eye to the brain. Retinal ganglion cells have limited intrinsic capacity to regenerate and cannot be replaced by new cells. Glaucoma and multiple sclerosis are the most common type of optic neuropathies that lead to vision loss and blindness due to death of retinal ganglion cells.

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Scientists Engineer Diaphragm in the Lab using Stem Cells

Jan 8, 2016 1:00:01 PM / by Shweta posted in Cell Therapy, Regenerative Medicine, Stem Cell Therapy, Stem Cells, tissue engineering, Basic Research

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Stem cells were instrumental in creating new functional diaphragm

The diaphragm is a one of the vital organs of the body; it is responsible for several important functions including its very critical role in respiration. During the process of breathing, the diaphragm contracts to add volume to the thoracic cavity, which enables the lungs to make room for more air. It also separates the thoracic and abdominal cavities. The malfunction of the diaphragm can lead to several life threatening conditions, which can be acquired or congenital. Congenital diaphragmatic hernias (CDH) are one of the most common birth defects (1:2500) caused by a malformation, or hole, in the diaphragm.

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Stem Cells: Rewiring the Brain with Reprogrammed Neurons

Dec 21, 2015 1:00:04 PM / by Shweta posted in nervous system, neurons, Stem Cells, Basic Research

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Stem cells may have a solution to rebuild defective neural communication in vivo

It has been already established that stem cells have tremendous therapeutic potential. Scientists are now exploiting stem cells to break the concept that the nervous system cannot regenerate. The plasticity of stem cells very well allows them to generate, repair, and change nervous system function.

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Stem Cells and Gene Editing Technology Together Create a Mini-Kidney in the Lab

Nov 30, 2015 1:00:54 PM / by Shweta posted in disease-state cells, iPSCs, Regenerative Medicine, Stem Cells

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Gene editing technology along with stem cells helped scientists develop a miniature scale kidney

In the past, researchers already developed complex kidney structures using stem cells. Now, the main aim of kidney tissue engineering is to develop new therapies to repair kidney damage and thus reduce the need for dialysis and transplantation. Recently, scientists at University of Washington in collaboration with Brigham and Women's Hospital and Harvard Stem Cell Institute (HSCI) have grown mini-kidneys in the laboratory [1]. The ex-vivo kidney could be used to study abnormalities in kidney development, chronic kidney disease, and the effects of toxic drugs on acute and chronic kidney conditions.

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