Blog | HemaCare

Stacy Matthews Branch, DVM, PhD


Recent Posts

Exploring CAR-T and TCR-T Therapies for COVID-19 Treatment

Jun 16, 2020 10:09:00 AM / by Stacy Matthews Branch, DVM, PhD posted in CAR-T, Cell Therapy, T Cells

0 Comments

As the fight against COVID-19 continues, the use of CAR-T or TCR-T therapies may be able to help treat patients infected, but more research is needed.

The last decade of research has provided significant advances in anti-cancer immunotherapies. Particularly, the development of genetically modified T-cells has been successful in treating various types of cancers. Chimeric antigen receptor (CAR) and T-cell receptor (TCR) T-cell therapy are major examples of highly studied immunotherapies. CAR-T cells recognize proteins or antigens expressed on the surface of cancer cells, whereas TCR-T cells recognize tumor antigens inside the cells.

Read More

CAR NK-Cell Therapy for Patients with NHL and CLL

Apr 28, 2020 10:06:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cell Therapy, NK Cells, Blood Disorders

0 Comments

A cord blood-derived CAR NK-cell therapy targeting CD19 showed promising results for patients with NHL and CLL.

Chimeric antigen receptor (CAR) T–cell therapy has been used with some success for certain types of hematological malignancies. The medical scientific community considers the possibility of using this approach for a wider spectrum of B-cell malignancies. However, there are a few significant limitations that affect the widespread successful use of CAR T for these forms of cancer.

Read More

Discussing Therapeutic Options for Novel Coronavirus (COVID-19)

Mar 24, 2020 10:04:00 AM / by Stacy Matthews Branch, DVM, PhD posted in T Cells, Vaccine Research, Immunotherapy (Immunology)

0 Comments

While the world waits for a coronavirus vaccine, scientists are looking to viral and cell therapy treatments for a solution.

Since China began reporting COVID-19 cases to the World Health Organization (WHO), the novel virus has since spread globally. With the declaration of COVID-19 as a global pandemic, announcements about efforts to develop a coronavirus vaccine are ongoing and constant.

Read More

What Are the Benefits to Using Disease State Samples?

Mar 19, 2018 10:18:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Basic Research

0 Comments

Disease state specimens boost the ability to achieve scientific advances and characterize the cellular and molecular features of a disease and its progression.

Progress in personalized medicine continues as more methods are developed to enhance diagnostic and prognostic efforts. Molecular technologies allow the identification of factors that can be used for early disease diagnosis, prediction of disease susceptibility, monitor disease development, determine treatment effectiveness, and to determine a patient’s disease prognosis. The availability of disease state specimens has bolstered the ability to achieve these advances and to characterize the cellular and molecular features of a disease and its progression.

Read More

Versatility and Specificity of CAR-T Cell Cytokines

Dec 13, 2017 8:43:54 AM / by Stacy Matthews Branch, DVM, PhD posted in PBMCs, Immunotherapy (Immunology)

0 Comments

In chimeric antigen receptor (CAR)-T cell immunotherapy, T cells are obtained from a patient and genetically modified to express specific receptors (CARs) against tumor antigens. The best studied and successful CAR-T cells target the CD19 antigen on neoplastic B cells. However, this targeted approach gives quite variable results. The secretion by CD19 CAR-T cells of various cell signaling molecules varies between patients and individual CAR-T cells. The question then is how to measure the ability of CD19 CAR-T cells to release signals, after a specific antigenic challenge and correlate that to patient responses.

Read More

      Subscribe Here!

      Posts by Topic

      see all

      Recent Posts