Blog | HemaCare

HemaCare PBMCs Power Exosome-based Cancer Immunotherapy

Mar 3, 2020 10:02:00 AM / by Nancy Andon, MSc posted in Cancer, PBMCs, Immunotherapy (Immunology)

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In a recent study, scientists at UCLA medical school cited using HemaCare sourced PBMCs for their research into a novel cancer immunotherapy strategy. [1]

This promising new strategy is based on cellular structures known as exosomes, which are small membrane-bound packets used to deliver protein “messages” from cell to cell. Because exosomes are known to facilitate cell-to-cell communications, researchers were keen to figure out whether they could be used to communicate the information immune cells need to target cancer.

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New T Cell Therapy Raises Hopes for Universal Cancer Treatment

Feb 25, 2020 10:12:00 AM / by Nancy Andon, MSc posted in Cancer, Cell Therapy, T Cells

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A new type of T cell capable of recognizing and killing most human cancer cells has just been discovered. Researchers at Cardiff University in Wales hit upon the entirely new class of T cell while examining immune cells at a local blood bank. [1] This T cell carries a novel T cell receptor (TCR) which recognizes most cancers, while ignoring healthy cells.

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Could Immunotherapy Effectively Treat Diseases Other Than Cancer

Feb 18, 2020 10:02:00 AM / by Stacy Matthews Branch, DVM, PhD posted in CAR-T, Immunotherapy (Immunology)

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Traditionally used to treat cancer, new research shows how immunotherapy could also be useful for treating other diseases as well.

The goal of immunotherapy is to modify or influence the immune system in such a way to enhance its disease-fighting ability. Immunotherapies have been extensively studied and developed for the treatment of various forms of cancer. One type of immunotherapy used to target cancer cells is chimeric antigen receptor T (CAR-T) cell therapy.  In CAR-T therapy, a patient’s T cells are harvested, genetically engineered to target cancer cells, and grown under laboratory conditions. These cells are then injected back into the patient. There are a number of research endeavors that are now investigating the effectiveness of CAR-T cells for non-cancer diseases, including autoimmune conditions.

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Metabolism, Immune Systems, and Pregnancy: What T Cells Are Revealing

Feb 11, 2020 10:09:00 AM / by Stacy Matthews Branch, DVM, PhD posted in T Cells, NK Cells, Immunotherapy (Immunology)

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In addition to fetal tissue tolerance, T cells and NK cells also play a role in fetal-maternal metabolic homeostasis.

Immune system adaptations in the maternal-fetal environment are essential for a successful pregnancy. When this adaptation is hindered or inadequate, infertility, miscarriage, pregnancy complications, and adverse fetal outcomes can occur. Specific immune cells have been studied to better understand their role in pregnancy and to know what this information can provide overall regarding the development of new immunotherapeutic approaches for disease states.

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Mobilized HemaCare Leukopaks Aid New T Cell Therapy Development

Feb 4, 2020 10:06:00 AM / by Nancy Andon, MSc posted in Cell Therapy, T Cells

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"File:Lab mouse mg 3216.jpg" by Rama is licensed under CC BY-SA 2.0

A recent publication out of UCLA cites using HemaCare mobilized leukopaks in the development of a new natural killer (NK) T cell-based therapy. [1]

The multi-departmental group of scientists, the majority of whom are based at UCLA, collaborated on the groundbreaking cancer research project. Their potential treatment relies on the unique properties of a powerful class of natural killer T cells.

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