Blog | HemaCare

HemaCare Publication Highlights Role of Cell Therapy Starting Materials

Jan 7, 2020 10:04:00 AM / by Nancy Andon, MSc posted in Gene Therapy, Cell Therapy

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HemaCare Corporation’s latest publication in BioPharm International [1] sheds light on a topic that has been preoccupying some of the best minds in cell therapy research; the need to ensure a reliable supply of top-notch starting materials for up-and-coming cell and gene therapies.

Unlike traditional medical treatments, the raw materials for these therapies cannot simply be manufactured. Instead, the supply of starting materials relies on a steady influx of voluntary donors willing to take the time to undertake a fairly complex screening process and donate peripheral blood or bone marrow for altruistic reasons. Nor is a reliable donor pool the only criteria necessary to supplying materials for a successful cellular therapeutic. Starting material quality and consistency ultimately determine the reliable efficacy of the final product.

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Nanotechnology for Acute Kidney Injury

Dec 30, 2019 10:06:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cell Therapy, Drug Discovery

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While there is no cure for acute kidney injury, a research team out of the University of Wisconsin-Madison may be shedding some new light on this condition.

Acute kidney injury (AKI) is characterized by a sudden decline in kidney function. This decline is marked by a significant rise in serum creatinine levels that may be accompanied by a reduction in urine output. Some cases of AKI require kidney transplantation or can lead to death. There are a number of causes of AKI, including injury from gadolinium-based contrast agents (nephrogenic systemic fibrosis), rhabdomyolysis, low blood volume, and vasculitis.

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Tests in New Immunotherapy Targets Macrophages Instead of Cancer Cells

Dec 23, 2019 10:07:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Macrophages, Immunotherapy (Immunology)

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A collaborative team of scientists from Denmark, France, the UK, and the US recognized the potential to target CD163 macrophages for a novel approach to cancer immunotherapy.

Macrophages are one of many types of immune system cells of the body, and they function to phagocytize and digest invading substances including bacteria and other microorganisms; they also digest cellular debris and cancer cells. However, there are a subset of macrophages (CD163 macrophages) that actually supports tumor survival and impedes T-cell attack of tumors. Expression of CD163 by these macrophages is associated with a poorer prognosis for a number of human cancers, such as malignant melanoma.

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Happy New Year! The Top Ten HemaCare Blogs of 2019

Dec 19, 2019 10:11:00 AM / by Nancy Andon, MSc posted in Cell Therapy

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It’s hard to believe that 2020 is almost here! As 2019 draws to a close, it’s a good time to look back on a year abundant in innovative medical discoveries and advances. To highlight some of the most interesting developments in the cell therapy field, we are pleased to present HemaCare’s 10 most popular blogs of the year, and the improvements in healthcare that they represent. Enjoy the countdown!

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CAR T Cell Drug Touts Long-Term Survival Rates

Dec 17, 2019 10:00:00 AM / by Nancy Andon, MSc posted in CAR-T, Cell Therapy, T Cells

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CAR T cell therapy has been one of the most exciting medical advances of this decade. As a type of immunotherapy, CAR T treatment consists of collecting patient-derived immune T cells, and genetically engineering them to recognize and fight invasive cancer cells. The first of these therapies to receive U.S. Food and Drug Administration (FDA) approval, Novartis’ Kymriah®, and Gilead’s Yescarta® garnered international attention for their astonishing success rates in clinical trial.

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