Blog | HemaCare

A Bioprinted Liver Model Featuring Induced Pluripotent Stem Cells

Apr 18, 2016 1:00:33 PM / by Steffen Porwollik posted in bioprinting, 3D tissue culture, Cancer, Innovation, iPSCs, liver cirrhosis, liver disease, research, Stem Cells


Scientists develop a 3D liver tissue model that better resembles a working organ – by bioprinting layers of three cell types that include hepatic progenitors obtained from induced pluripotent stem cells.

The human liver is an astoundingly large organ with a very complex set of tasks. It weighs in at about 3lbs and filters the blood that comes from the digestive tract, detoxifies chemicals, metabolizes drugs and makes important proteins that help with blood clotting. Its health is of vital importance, quite literally. Sadly, liver disease is on the rise. There are more than 100 different kinds of liver maladies, including viral forms such as hepatitis A, B and C, bacterial diseases, diseases caused by autoimmune disorders, and cancer. Shockingly, fatty liver disease and its chronic conclusion, cirrhosis, both alcohol-related and non-alcohol-related, are found in up to 25% of Americans today.

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4D Stem Cell Biology and the Next Generation of Regenerative Medicine

Feb 27, 2014 7:00:10 AM / by Maria posted in drug screening, Gene Therapy, 3D tissue culture, Cell Therapy, cellular reprogramming, Drug Discovery, Innovation, iPSCs, organ transplants, organogenesis, personalized medicine, research, stem cell therapy, Stem Cells, tissue engineering


In Part I and II of this series of posts, we covered self-organization of ectodermal and endodermal tissues in 3D culture but much of the recent progress in the field of stem cell biology comes from understanding organogenesis in 3D culture in what is really more like 4 dimensions. Whereas self-organization in 3D culture uses artificial scaffolds required for cells to achieve structural formation, 4D stem cell biology involves natural development of complex tissues by following the internal agenda of the cells. Although transplantation of these self-organized tissues may be superior to conventional engineering that is not to say that the additional use of scaffolds and growth factors in tissue engineering would not improve upon the results of stem cell culture and organogenesis.

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Stem Cell Organizers: The Maestros of Embryonic Development

Feb 13, 2014 12:00:47 AM / by Maria posted in 3D tissue culture, Cell Therapy, cellular therapy, induced pluripotent stem cells, Innovation, iPSCs, organogenesis, Regenerative Medicine, research, stem cell therapy, Stem Cells


Although the stem cell field is rich with remarkable findings, many mysteries remain. Fortunately, recent discoveries help describe the complex mechanisms and dynamic interactions of stem cells working collectively to form sophisticated organ buds in 3D culture. Researchers have even gone further by learning how to control stem cell differentiation and reprogramming by steering the stem cell culture toward the path of choice using specific signals or cues. HemaCare offers a variety of high quality blood cells, including stem cells, that are a convenient human source for regenerative medicine research needs.

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