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Targeting T Cells to Treat IBD

Sep 4, 2018 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in autoimmune disease, Autoimmune Disorders, CD4+ T cells, Helper T Cells

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Recent research looks into the relationship between T helper cells and the autoimmune conditions of inflammatory bowel disease (IBD).

Crohn’s disease and ulcerative colitis are two forms of inflammatory bowel disease (IBD) caused by an immune dysfunction. People with IBD can experience diarrhea, rectal bleeding, constipation, abdominal pain and cramping, fatigue, loss of appetite, and weight loss. Dysregulated responses of a subset of CD4 T cells (T helper cells) are associated with autoimmune and chronic inflammatory conditions and may induce and maintain intestinal inflammation, but the mechanism is not fully understood. The primary cytokine secreted by T helper cells of the intestinal mucosa of people with IBD is interferon (IFN)-gamma. Recent research was conducted to better understand the role of IFN-producing CD4 T cells in the initiation and maintenance of IBD.

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Immune Research Innovations Support Multiple Sclerosis Arena

Jan 15, 2018 10:23:00 AM / by Stacy Matthews Branch, DVM, PhD posted in autoimmune disease, immunology, Immunotherapy

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Recent advances in immunology research have uncovered extensive and amazing knowledge of how many cells and other factors of the immune system identify antigens and diseased cells. However, there remain many gaps in knowledge, and filling these will help achieve even more impactful breakthroughs in the immunotherapy and vaccine arena. The Human Vaccines Project is a nonprofit organization with the goal to contribute to the development of vaccines and immunotherapies by understanding the human immune system at a deeper level.

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Factor Expressed on Regulatory T Cells Keeps Autoimmunity in Check

Nov 2, 2016 12:42:11 PM / by Stacy Matthews Branch, DVM, PhD posted in autoimmune disease, Autoimmune Disorders, autoimmune disorder treatment, CD4+ T cells, customizable cytotoxic T cells, Cytotoxic T Cells, research

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Autoimmune disorders develop when the body’s immune system does not distinguish between the body’s own cells and antigens. The destruction by the immune system of normal tissues is the basis of autoimmune diseases. The search for effective treatments or cures for autoimmune disorders depends on understanding the factors involved in immune cell function.

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Autologous Hematopoietic Stem Cell Transplantation Heals Autoimmune Disorder

May 23, 2016 1:00:05 PM / by Steffen Porwollik posted in aHSCT, autoimmune disease, Bone Marrow, bone marrow, hematopoietic stem cells, myasthenia gravis, stem cell therapy, Stem Cell Therapy, stem cell transplantation

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Canadian doctors observe complete stable remission of the autoimmune disorder myasthenia gravis in all seven patients that underwent autologous hematopoietic stem cell transplantation in their hospital in the past 14 years.

Olympic Games 2004, Athens, Greece. It’s the men’s 400m hurdles finals. American athlete James Carter barrels over the hurdles, going strong, leading the pack. He looks a far cry from his younger 12-year-old self. Back then, he was unable to run, barely able to walk, and his muscles did not follow his mind’s orders. Eventually, he was diagnosed with the autoimmune disorder myasthenia gravis (MG) and had his thymus removed. Mr. Carter knows about hurdles.

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A New Hope Against Type I Diabetes: The T cells that Attack the Beta Cells in the Pancreas Have Been Found

May 16, 2016 1:00:15 PM / by Dalia Gaddis posted in fusion peptide, autoimmune disease, Innovation, pancreas, research, Type I Diabetes

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A long-awaited discovery leads researchers to find the pathogenic T cells that recognize and destroy pancreatic beta cells.

When it comes to autoimmune diseases, the patient’s main problem lies within. In such diseases, the immune system’s T cells go rogue and start attacking different organs, resulting in disease. Scientists are constantly trying to discover the identity of the autoimmune T cells as this may be the first step in a preventative therapy.

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