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Targeting T Cells to Treat IBD

Sep 4, 2018 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in autoimmune disease, autoimmune disorder, CD4+ T cells, T helper cells

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Recent research looks into the relationship between T helper cells and the autoimmune conditions of inflammatory bowel disease (IBD).

Crohn’s disease and ulcerative colitis are two forms of inflammatory bowel disease (IBD) caused by an immune dysfunction. People with IBD can experience diarrhea, rectal bleeding, constipation, abdominal pain and cramping, fatigue, loss of appetite, and weight loss. Dysregulated responses of a subset of CD4 T cells (T helper cells) are associated with autoimmune and chronic inflammatory conditions and may induce and maintain intestinal inflammation, but the mechanism is not fully understood. The primary cytokine secreted by T helper cells of the intestinal mucosa of people with IBD is interferon (IFN)-gamma. Recent research was conducted to better understand the role of IFN-producing CD4 T cells in the initiation and maintenance of IBD.

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Factor Expressed on Regulatory T Cells Keeps Autoimmunity in Check

Nov 2, 2016 12:42:11 PM / by Stacy Matthews Branch, DVM, PhD posted in autoimmune disease, autoimmune disorder, autoimmune disorder treatment, CD4+ T cells, customizable cytotoxic T cells, cytotoxic T cells, research

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Autoimmune disorders develop when the body’s immune system does not distinguish between the body’s own cells and antigens. The destruction by the immune system of normal tissues is the basis of autoimmune diseases. The search for effective treatments or cures for autoimmune disorders depends on understanding the factors involved in immune cell function.

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