Blog | HemaCare

Hepatitis B Virus-Specific CD4+ Cytotoxic T Cells Have Lower Liver Tumor Killing Capacity Than CD8+ Cytotoxic T Cells

Jun 22, 2017 11:28:02 AM / by Stacy Matthews Branch, DVM, PhD posted in Cytotoxic T Cells, Basic Research

0 Comments

Hepatitis B virus (HBV)-related hepatocellular carcinoma is a common, but aggressive liver cancer with a low survival rate. Given the immunogenicity of HBV and tumor cells, immunotherapies based on T-cell cytotoxicity may be viable treatment approaches to hepatocellular carcinoma. Studies were conducted to characterize the cytotoxic T-cell (CD4+ and CD8+) responses involved in HBV-related hepatocellular carcinoma. 

Read More

World Blood Donor Day: Celebrating the Life-Giving Gift

Jun 14, 2017 9:00:28 AM / by Stacy Matthews Branch, DVM, PhD posted in Basic Research

0 Comments

Many people have at some point thought of, or actually donated their blood for medical use by those most in need. Most people are familiar with the use of donated blood in emergency situations to replace trauma-related blood loss. However, donated blood has many uses including for medical research and planned therapies. Research using donated blood supports crucial development of immunotherapies for different types of cancer, auto-immune diseases, rare diseases and conditions, and more.

Read More

Detection of Immune System Activation During Pregnancy and Labor

May 30, 2017 9:08:04 AM / by Stacy Matthews Branch, DVM, PhD posted in PBMCs, Basic Research

0 Comments

Preterm labor is a major cause of and infant mortality and long-term medical complications in offspring. Premature activation of the maternal immune system may stimulate cervical dilatation and activation of the uterine smooth muscle, leading to preterm delivery. Normal labor involves an increase in the expression of uterine-derived pro-inflammatory cytokines and chemokines that activate maternal peripheral leukocytes. Leukocytes then increase within the uterus and stimulate the cervical and uterine conditions that lead to delivery of the baby. Better characterization of these biochemical and cellular events may provide information that can be used to screen or predict the risk of preterm labor.

Read More

Obesity Status May Impact the Immune System After Hip and Knee Surgery

May 24, 2017 9:21:20 AM / by Stacy Matthews Branch, DVM, PhD posted in Cytotoxic T Cells, Basic Research

0 Comments

Patients with obesity who undergo knee or hip arthroplasty (joint replacement surgery) are at an increased risk for post-operative complications, including problems with wound healing. Those who are obese tend to have higher cytokine levels (cell signaling molecules) indicating the existence low-grade inflammation in this population. To understand the connection between obesity and immune status as it relates to post-operative wound healing, scientists conducted research to determine the status of immune cells and cytokines in those undergoing arthroplasty.

Read More

Highly Conserved Influenza A Peptides Show Promise as T Cell Reactive Vaccine Candidates

May 23, 2017 9:41:08 AM / by Stacy Matthews Branch, DVM, PhD posted in Cytotoxic T Cells, Dendritic Cells, PBMCs, T Cells, Basic Research

0 Comments

Influenza A is responsible for flu epidemics worldwide. This virus changes constantly making effective vaccine design very challenging. Currently, vaccines must be redesigned to account for the changes in the virus strains. However, there are influenza viral peptides that are conserved across different strains. These peptides may serve as the basis for the development of vaccines effective against different strains.

Read More

      Subscribe Here!

      Posts by Topic

      see all

      Recent Posts