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A Bioprinted Liver Model Featuring Induced Pluripotent Stem Cells

Apr 18, 2016 1:00:33 PM / by Steffen Porwollik posted in bioprinting, Cancer, Innovation, iPSCs, liver cirrhosis, liver disease, research, Stem Cells

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Scientists develop a 3D liver tissue model that better resembles a working organ – by bioprinting layers of three cell types that include hepatic progenitors obtained from induced pluripotent stem cells.

The human liver is an astoundingly large organ with a very complex set of tasks. It weighs in at about 3lbs and filters the blood that comes from the digestive tract, detoxifies chemicals, metabolizes drugs and makes important proteins that help with blood clotting. Its health is of vital importance, quite literally. Sadly, liver disease is on the rise. There are more than 100 different kinds of liver maladies, including viral forms such as hepatitis A, B and C, bacterial diseases, diseases caused by autoimmune disorders, and cancer. Shockingly, fatty liver disease and its chronic conclusion, cirrhosis, both alcohol-related and non-alcohol-related, are found in up to 25% of Americans today.

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