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Cytokine-Induced Killer Cell/Dendritic Cell Immunotherapy Combined with Chemotherapy is More Effective than Chemotherapy Alone

May 31, 2017 1:00:17 AM / by Stacy Matthews Branch, DVM, PhD posted in bioreasearch, bioresearch products, cell products, Dendritic Cell Immunotherapy, Dendritic cells, immunotherapy

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Colorectal cancer (CRC) is the fourth most common type of cancer in the U.S. , but screening and early diagnosis have helped to reduce the death rate from CRC in the U.S. However, developing and transitional countries experience increases in the incidence of CRC. The primary treatment approaches used (surgery, chemotherapy, radiotherapy) are associated with adverse events and poor survival rates.

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Detection of Immune System Activation During Pregnancy and Labor

May 30, 2017 9:08:04 AM / by Stacy Matthews Branch, DVM, PhD posted in bioreasearch, CD14+ monocytes, CD15+ granulocytes, Peripheral blood cells, Peripheral Blood Mononuclear Cell

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Preterm labor is a major cause of and infant mortality and long-term medical complications in offspring. Premature activation of the maternal immune system may stimulate cervical dilatation and activation of the uterine smooth muscle, leading to preterm delivery. Normal labor involves an increase in the expression of uterine-derived pro-inflammatory cytokines and chemokines that activate maternal peripheral leukocytes. Leukocytes then increase within the uterus and stimulate the cervical and uterine conditions that lead to delivery of the baby. Better characterization of these biochemical and cellular events may provide information that can be used to screen or predict the risk of preterm labor.

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Effect of Medicinal Cannabinoids on Peripheral Blood Mononuclear Cell Signaling

Mar 30, 2017 9:05:05 AM / by Stacy Matthews Branch, DVM, PhD posted in bioreasearch, Mononuclear Cells, Peripheral Blood Mononuclear Cell, peripheral blood mononuclear cells, research

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There is an ever increasing desire to understand the medicinal properties of marijuana. The components of marijuana are numerous; however, the more widely known class of compounds with medicinal activity are cannabinoids. Scientists continue to search for the mechanisms of these cannabinoids in various diseases including cancer and inflammatory conditions.

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CD34+ and CD34+CD133+ Stem Cell Levels Predict Cardiovascular Outcome in Patients With Type 2 Diabetes

Feb 20, 2017 8:00:54 AM / by Stacy Matthews Branch, DVM, PhD posted in bioreasearch, cd 34 stem cells, CD133+, research, stem cell research, stem cells

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Cardiovascular diseases are a leading cause of death worldwide. There are various risk factors for cardiovascular disease such as obesity, physical inactivity, smoking, and diabetes. The risk of cardiovascular disease and stroke in patients with type 2 diabetes is more than twice that of people without diabetes.

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