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HPV-Pulsed Dendritic-Cell Vaccination in a Patient with Metastatic Cervical Cancer

Mar 1, 2017 9:29:35 AM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, Dendritic Cells, Vaccine Research

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The diagnosis and treatment of inoperable cervical carcinoma severely affects the quality of life of patients and their caregivers. The one-year survival rate remains under 15%. Dendritic cells have been studied as adjuvants that modify the effects of tumor immunotherapy in humans. A case report has been published that describes the vaccination with dendritic cells of a patient with metastatic cervical cancer.

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PBMC Estrogen Receptor α Gene Expression May Predict Response to Interferon Therapy in Patients with Chronic Hepatitis B Infection

Jan 16, 2017 12:00:23 AM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, PBMCs, pegylated interferon, Infectious Disease, Basic Research

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Hepatitis B is a viral infection that can cause liver damage. Most healthy adults that contract the acute infection can be symptom free and clear the virus. Some people cannot clear the virus after several months, developing the chronic form of the infection. Pegylated interferon is a slow-release form of an immune molecule that has been shown to inhibit virus replication and limit liver damage.

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Stem Cell Gene Therapy is the Foundation for Emerging Targeted Therapies

Nov 28, 2016 12:00:31 AM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, Stem Cell Therapy, Stem Cells

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The successes and failures that led to the state of stem cell therapy have provided a framework for other types of molecular therapies now being studied and advanced. An example of this begins with the development of a new type of therapy for the immunometabolic disorder, ADA-SCID. The therapy, strimvelis, was developed by scientists in Milan, Italy at the San Raffaele Hospital and Telethon Institute (TIGET). They accomplished this by combining the science of gene therapy with stem cell transplantation.

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