Blog | HemaCare

Possible New Improvements for Acute Myeloid Leukemia Treatment

May 26, 2020 10:02:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Blood Disorders

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Researchers continue to build on success of treating AML patients with an alkaloid (HHT) derived from a conifer tree.

Acute myeloid leukemia (AML) is not one disease but a group of hematopoietic neoplasms with varying genotypes, yet similar phenotypes. The cancer arises from hematopoietic stem cells that normally differentiate into myeloid cells such as granulocytes, monocytes, and erythrocytes.

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CAR NK-Cell Therapy for Patients with NHL and CLL

Apr 28, 2020 10:06:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cell Therapy, NK Cells, Blood Disorders

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A cord blood-derived CAR NK-cell therapy targeting CD19 showed promising results for patients with NHL and CLL.

Chimeric antigen receptor (CAR) T–cell therapy has been used with some success for certain types of hematological malignancies. The medical scientific community considers the possibility of using this approach for a wider spectrum of B-cell malignancies. However, there are a few significant limitations that affect the widespread successful use of CAR T for these forms of cancer.

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Extracellular Vesicles Boost Grafting Ability in Cells

Aug 20, 2019 10:11:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Bone Marrow, Stem Cells, Blood Disorders

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A new study shows that we may be able to boost the grafting ability in cells for people receiving a bone marrow transplant.

Allogenic stem cell transplantation is a treatment approach in people with diseases that are destructive to the bone marrow, such as multiple myeloma, leukemia, and Hodgkin´s lymphoma. The goal is to restore bone marrow after total-body chemotherapy and irradiation. The transplantation procedure involves transferring hematopoietic stem cells from compatible, healthy donors to a patient. An important complication of this procedure is rejection and destruction of the donated stem cells by the recipient’s immune system before engraftment can occur.

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HemaCare Leukopaks Support Novel Gene Editing Strategy

May 7, 2019 10:07:00 AM / by Nancy Andon, MSc posted in Leukopak, Stem Cells, Blood Disorders

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In an independent publication [1] researchers at UCLA cited using leukopaks obtained from HemaCare in order to investigate a new gene editing method.

The group is researching strategies to treat genetic blood disorders such as sickle cell anemia. While there has been a great deal of research focused on using CRISPR/Cas9 gene therapy to treat these illnesses [2], current strategies for gene editing in hematopoietic stem cells are inefficient, and thus costly.

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HemaCare Bone Marrow Tissue Boosts Development of Cell Therapy for Sickle Cell Disease

Dec 12, 2018 10:10:00 AM / by Nancy Andon, MSc posted in Bone Marrow, Stem Cell Therapy, Stem Cells, Blood Disorders

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An independent study cites the use of HemaCare-sourced human bone marrow-derived CD34+ stem cells for research into a potential new therapy for sickle cell disease. [1]

Sickle cell is a serious disease that affects millions of people throughout the world. People affected by sickle cell anemia have rigid, sickle-shaped red blood cells that can’t adequately carry oxygen to the body’s tissues. As a result, sickle cell patients suffer from a variety of medical complications, which can shorten their life span. Contemporary cell therapy treatments have focused on a gene therapy approach that uses lentiviral vectors to supply CD34+ bone marrow-derived stem cells with an unimpaired version of the hemoglobin gene. While this tactic has met with some promise, finding healthy, matched bone marrow donors is difficult. Researchers at Biogen, a well-known biotech firm headquartered in Cambridge, Massachusetts, are trying to discover cell and gene therapy methods that they hope will provide an alternative solution, and thereby improve treatment success rates.

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