Blog | HemaCare

Dendritic Cell Immunotherapy Gets a Boost

Jul 25, 2016 1:00:30 PM / by Steffen Porwollik posted in glioma, brain cancer, Cancer Immunology, cancer immunotherapy, Cytotoxic T Cells, Dendritic Cells, immunogenic cell death, Innovation, T Cells


A new strategy significantly increases the efficacy of dendritic cell immunotherapy against high grade glioma, a severe type of brain cancer. The key: pre-exposing the therapy to glioma cells undergoing immunogenic cell death.

High grade glioma (HGG) is a malignant brain cancer that is characterized by tumorous growth of glial cells, non-neural cells surrounding the neurons of the central and peripheral nervous system. HGG is accompanied by a heartbreakingly poor prognosis and the current lack of a cure. Hundreds of children are diagnosed every year with HGG in Europe and North America.

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That Tetanus Shot Boosts Lifespan for Brain Cancer Patients via Dendritic Cells

Apr 22, 2015 1:00:58 PM / by Daisy posted in glioblastoma, brain cancer, Cancer Immunology, cancer immunotherapy, clinical trial


In a clinical trial, brain cancer patients with a few months to live survived for years. Thanks to that tetanus shot and dendritic cells in a cancer vaccine!

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Engraftment of Stem Cells May Restore Brain Damage Caused by Radiation Therapy

Apr 8, 2015 1:00:56 PM / by Shweta posted in brain cancer, embryonic stem cells, induced pluripotent stem cells, Regenerative Medicine, research, stem cell therapy, Stem Cell Therapy, stem cell transplantation, Stem Cells


Stem cells may counteract the long-term side effects of radiation therapy in brain tumor patients

Radiotherapy is a widely used approach for the treatment of brain tumors. However, the benefits are often combined with serious irreversible brain damage that can have grave consequences on a cancer survivor’s life. Depletion of oligodendrocyte progenitors and demyelination are the main side effects, along with the impairment of motor coordination, all induced due to long-term use of radiation therapy. Myelin coating is generated by oligodendrocytes and required to protect and repair the brain neurons. Therefore, it is important to develop a novel treatment to rejuvenate the brain damaged caused by radiation therapy.

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