Blog | HemaCare

Dendritic Cell Immunotherapy Gets a Boost

Jul 25, 2016 1:00:30 PM / by Steffen Porwollik posted in glioma, brain cancer, Cancer Immunology, cancer immunotherapy, cytotoxic T cells, Dendritic cells, immunogenic cell death, Innovation, T cells

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A new strategy significantly increases the efficacy of dendritic cell immunotherapy against high grade glioma, a severe type of brain cancer. The key: pre-exposing the therapy to glioma cells undergoing immunogenic cell death.

High grade glioma (HGG) is a malignant brain cancer that is characterized by tumorous growth of glial cells, non-neural cells surrounding the neurons of the central and peripheral nervous system. HGG is accompanied by a heartbreakingly poor prognosis and the current lack of a cure. Hundreds of children are diagnosed every year with HGG in Europe and North America.

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That Tetanus Shot Boosts Lifespan for Brain Cancer Patients via Dendritic Cells

Apr 22, 2015 1:00:58 PM / by Daisy posted in glioblastoma, brain cancer, Cancer Immunology, cancer immunotherapy, clinical trial

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In a clinical trial, brain cancer patients with a few months to live survived for years. Thanks to that tetanus shot and dendritic cells in a cancer vaccine!

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Engraftment of Stem Cells May Restore Brain Damage Caused by Radiation Therapy

Apr 8, 2015 1:00:56 PM / by Shweta posted in brain cancer, embryonic stem cells, induced pluripotent stem cells, regenerative medicine, research, stem cell therapy, Stem Cell Therapy, stem cell transplantation, stem cells

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Stem cells may counteract the long-term side effects of radiation therapy in brain tumor patients

Radiotherapy is a widely used approach for the treatment of brain tumors. However, the benefits are often combined with serious irreversible brain damage that can have grave consequences on a cancer survivor’s life. Depletion of oligodendrocyte progenitors and demyelination are the main side effects, along with the impairment of motor coordination, all induced due to long-term use of radiation therapy. Myelin coating is generated by oligodendrocytes and required to protect and repair the brain neurons. Therefore, it is important to develop a novel treatment to rejuvenate the brain damaged caused by radiation therapy.

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