Blog | HemaCare

Researchers Use Single-Cell Sequencing to Study Clonal Diversity of Acute Myeloid Leukemia

Jun 8, 2021 10:00:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer

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University of Texas MD Anderson Cancer Center researchers have started to explore the clonal diversity and the advancement of acute myeloid leukemia.

Clonal diversity is increasingly studied and understood to have central importance as a key characteristic of cancer. Changes in the specific genetic makeup of precancerous and cancer cells change via mutations as tumors progress. A given change or mutation can impart a survival advantage and lead to subsequent cells with this advantage.

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New Research Shows the Vital Role Metabolic Signaling Plays in Regulating Specialized T Cells

Jun 1, 2021 10:15:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Autoimmune Disorders, Cancer, T Cells

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Scientists at St. Jude Children’s Research Hospital revealed that metabolic signaling mechanisms regulate the function of an eTreg cell.

Foxp3-expressing regulatory T cells are critical components of the immune system for the regulation of immune responses and the suppression of other immune cells for the maintenance of self-tolerance and regulation of immunity against pathogens and tumor cells.

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New Technique Could Help Scientists Identify Rare T Cells and Advance T Cell Therapies

May 11, 2021 10:10:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, T Cells

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Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research scientists developed a new technique that enables researchers to identify and isolate T cells capable of targeting cancer cells, viruses, and other rare diseases more efficiently.

There are a number of challenges with adoptive T cell therapies, one being the isolation of specific T cells in sufficient numbers. Although state-of-the-art technologies are available to isolate rare, specific T cells, those methodologies are quite labor-intensive and tend to also lead to the isolation of bystander T cells that are activated with antigen recognition by T cells but do not themselves react to antigens. The development of a technology that bolsters the numbers of antigen-specific T cells, such a those reactive to tumor cells or viruses, is an ongoing research endeavor.

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Hematopoietic Stem Cell Mutations May Lead to Increased Risk for Leukemia and Heart Disease

Feb 23, 2021 10:03:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Cardiovascular Disease, Stem Cells

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Two teams of scientists have discovered a set of inherited gene variants that can increase the risk of developing mutations in HSC’s in their lifetimes. The mutations can lead to two different age-related disorders: clonal hematopoiesis of indeterminate potential and myeloproliferative neoplasms. 

Advancing age has been associated with an increased risk of various chronic diseases and conditions. Mutations in hematopoietic stem cells increase as people age and may be linked to an increased risk of leukemia and cardiovascular disease. Somatic mutations in hematopoietic stem cells are connected to the development of myeloproliferative neoplasms (MPN) characterized by an excess of red blood cells, leukocytes, and platelets that leads to an increased susceptibility to develop leukemia.

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HemaCare Macrophages Help Solve Mysteries of Immune Regulation

Jan 26, 2021 10:25:00 AM / by Nancy Andon, MSc posted in Cancer, Macrophages, Immunotherapy (Immunology)

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The use of HemaCare-sourced macrophages has been cited in a recent publication in the Journal of Immunology. The paper is a collaboration between the University of Maryland in College Park, and biopharmaceutical company AstraZeneca. [1]

The role of macrophages in the human immune system is not nearly as well-known as T cells or B cells, which are seemingly ubiquitous in the cell and gene therapy field. Like lymphocytes, macrophages are derived from hematopoietic stem cells. Unlike the lymphoid lineage, however, myeloid precursors ultimately produce in the macrophage an immune cell capable of both antigen presentation and phagocytic activity.

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