Blog | HemaCare

Clinical Trials Begin for CAR-T Immunotherapy for Metastatic Prostate Cancer

Nov 24, 2020 10:03:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, T Cells, NK Cells

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Clinical trials have begun with its first round of Metastatic Prostate Cancer patients for immune cell therapy. 

Chimeric antigen receptor T cell (CAR-T) therapy uses the body’s own immune cells to target tumor cells. T cells are taken from a patient’s body then genetically modified to target specific protein markers on tumor cells. As research and development of the next generation of cell therapies continue, new efforts are underway to discover new targets for CAR-T cell development.

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Combining Microbial Therapy with Immunotherapy May Help the Immune System Attack Cancer Cells

Nov 10, 2020 9:08:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, T Cells, Immunotherapy (Immunology)

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Researchers discovered how the gut microbiome helps our immune system fight tumors that are cancerous.

The gut microbiome has beneficial effects on health, and alterations in the microbiota can increase the risk of a number of illnesses. Past studies suggest that the gut microbiota can affect anti-tumor immunity, and recently, that it can be used to simulate the efficacy of immune checkpoint inhibitor therapy. Immune checkpoints are proteins that prevent immune cells from targeting and killing the body’s own cells. However, tumor cells can use these checkpoint proteins (CTLA-4, PD-1, or PD-L1) to evade the immune system’s attack.

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Breast Cancer Cells Alter Function of NK Cells to Prevent Metastases

Oct 6, 2020 10:07:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, NK Cells

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Johns Hopkins University’s scientists have discovered that breast cancer cells can change the function in natural killer cells so they prevent metastases.

Natural killer (NK) cells play a significant role in the body’s defense against tumors and viral infections. The antitumor capacity involves an antimetastatic component, but it is now known that tumor cells can evade the antimetastatic effect of NK cells. Invasive breast cancer cells are vulnerable to healthy NK cells (unchanged NK cells not exposed to a tumor environment). The researchers found that NK cells exposed to cancer cells lose their cytotoxic and antimetastatic properties, allowing metastatic growth to proceed. The goal of a recent study was to determine how metastatic breast cancer cells escape NK-cell antimetastatic activity.

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HemaCare Human Bone Marrow Employed in Groundbreaking Cancer Detection Study

Sep 29, 2020 10:05:00 AM / by Nancy Andon, MSc posted in Bone Marrow, Cancer

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A groundbreaking cancer detection study published in Cell [1] cites the use of HemaCare-sourced human bone marrow.

The Cell publication is part of a global collaborative effort based in 8 different countries, including several U.S. based cancer research institutes. Their goal is simple; find a way to detect cancer early, no matter where it originates in the human body, thereby securing the best possible chance of treating patients successfully.

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Editing NK Cells Produces More Potent Cancer Killers

Sep 15, 2020 10:07:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, NK Cells

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Researchers at the University of California San Diego used natural killer cells in a study as immunotherapeutic agents. They found that the natural killer cells are effective in ridding tumor cells from the body. 

Immunotherapy for cancer treatment is rapidly emerging, and many studies are aimed at increasing the safety and efficacy of anti-tumor immunotherapy. Although T cells have been extensively studied, more research is being conducted on the use of natural killer (NK) cells as immunotherapeutic agents. NK cells are lymphocytes of the immune system capable of attacking and killing virus-infected and tumor cells. NK cells can lyse tumor cells without prior activation, but the potency of this effect limits its clinical use.

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