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STAT5 Proteins May Play a Critical Role in Effective Anti-Tumor Immune Response

Jun 29, 2021 10:10:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, CAR-T

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A study has shown that cancer patients’ white blood cells were genetically engineered to enable T-cells to identify and destroy the cancer cells.

Chimeric antigen receptor (CAR) T-cells are immune cells that have been genetically engineered to generate a T-cell receptor capable of targeting specific cancer cells. A patient’s own T cells are collected, modified, then infused back into the patient. Although very promising results and successes have been noted for the application of CAR-T cell therapy for blood cancers, it is not without significant challenges to overcome.

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Higher Post-Immunotherapy Survival Rate in Cases of Recurrent Glioblastoma Linked to Low TMB

Jun 22, 2021 10:30:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Immunotherapy (Immunology)

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A report out of Nature Communications suggests a correlation between the use of low TMB and an increased survival rate among glioblastoma patients may be due to changes in the immunological status of tumor post therapy.

Tumor mutation burden (TMB) is the frequency of certain protein (tumor antigen)-altering mutations within tumor genes. The production of more tumor antigens increases the chances that one or more of those can be recognized and reacted upon by the immune system. Highly mutated tumors produce many antigens that can stimulate T cells to respond to the antigens.

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Researchers Use Single-Cell Sequencing to Study Clonal Diversity of Acute Myeloid Leukemia

Jun 8, 2021 10:00:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer

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University of Texas MD Anderson Cancer Center researchers have started to explore the clonal diversity and the advancement of acute myeloid leukemia.

Clonal diversity is increasingly studied and understood to have central importance as a key characteristic of cancer. Changes in the specific genetic makeup of precancerous and cancer cells change via mutations as tumors progress. A given change or mutation can impart a survival advantage and lead to subsequent cells with this advantage.

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New Research Shows the Vital Role Metabolic Signaling Plays in Regulating Specialized T Cells

Jun 1, 2021 10:15:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Autoimmune Disorders, Cancer, T Cells

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Scientists at St. Jude Children’s Research Hospital revealed that metabolic signaling mechanisms regulate the function of an eTreg cell.

Foxp3-expressing regulatory T cells are critical components of the immune system for the regulation of immune responses and the suppression of other immune cells for the maintenance of self-tolerance and regulation of immunity against pathogens and tumor cells.

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New Technique Could Help Scientists Identify Rare T Cells and Advance T Cell Therapies

May 11, 2021 10:10:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, T Cells

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Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research scientists developed a new technique that enables researchers to identify and isolate T cells capable of targeting cancer cells, viruses, and other rare diseases more efficiently.

There are a number of challenges with adoptive T cell therapies, one being the isolation of specific T cells in sufficient numbers. Although state-of-the-art technologies are available to isolate rare, specific T cells, those methodologies are quite labor-intensive and tend to also lead to the isolation of bystander T cells that are activated with antigen recognition by T cells but do not themselves react to antigens. The development of a technology that bolsters the numbers of antigen-specific T cells, such a those reactive to tumor cells or viruses, is an ongoing research endeavor.

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