Blog | HemaCare

HemaCare Leukopaks Used for Production of Allogeneic CAR T cells

May 28, 2019 10:04:00 AM / by Nancy Andon, MSc posted in leukopaks, CAR-T, allogeneic

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A study out of Research Triangle Park, North Carolina [1] cites using HemaCare leukopaks as the starting material for new research on allogeneic CAR T cells.  

As most people know, the cancer fighting technique known as CAR T cell therapy has been getting a lot of attention these days, due to some remarkably positive clinical trial results. Two different versions of CAR T therapy have now earned FDA approval, so it seems that this type of therapy will inevitably be expanded to meet the needs of a considerably wider patient population. There’s a fairly large obstacle standing in the way of this expectation, however. Most clinical trials to date have been based on CAR T cell treatment as an autologous therapy, with the starting materials coming straight from the patients themselves. The problem with this autologous model is that it’s difficult to implement on a commercial scale, due to the limited availability of starting material.

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Happy New Year! The Top 10 HemaCare Blogs of 2018

Dec 28, 2018 9:51:00 AM / by Nancy Andon, MSc posted in cancer treatment, CAR-T, Immunotherapy, T Cells

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2018 has flown by, and 2019 is just around the corner! As the New Year approaches, it’s good to look back at just how much has been accomplished in the field of medicine, and wonder what the future holds. As is our tradition at this time of year, we are pleased to present HemaCare’s 10 most popular blogs of the year, and the advances in healthcare that they represent. Enjoy the countdown!

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Treating Glioblastoma with CAR-T Immunotherapy

Aug 13, 2018 10:11:00 AM / by Stacy Matthews Branch, DVM, PhD posted in cancer immunotherapy, CAR-T, Immunotherapy, T Cells

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There are some promising advances in treating glioblastoma and other cancers with immunotherapy.

The most frequently diagnosed type of brain cancer in adults is glioblastoma multiforme. Despite the emergence of immunotherapeutic approaches for a number of cancers, reliable treatments that can extend overall survival of patients with glioblastoma to the two-year mark and beyond are still under investigation. There are some promising advances such as an experimental dendritic cellbased vaccine that increased the median overall survival rate from 15 months to 23 months.

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New Progress in Immunotherapy Strategies

Apr 23, 2018 10:02:00 AM / by Stacy Matthews Branch, DVM, PhD posted in cancer treatment, CAR-T, dendritic cell vaccine, Dendritic Cells, Immunotherapy

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State-of-the-art immunotherapies may show great promise in the future for cancer treatment.

Immunotherapy research results show that cancer treatment may need a combination approach. Dr. Andrew S. Chi, the chief of neuro-oncology and the codirector of the Brain Tumor Center at NYU Langone, weighed in on the state of developed immunotherapy approaches. A number of strategies involve increasing T-cell activation against tumors by the use of checkpoint inhibitors (that block proteins that inhibit immune system attack of cancer cells). Dr. Chi points out that combinations of immune checkpoint inhibitors may be more effective. 

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Biological Scaffolding Speeds Ex Vivo T Cell Expansion

Mar 6, 2018 10:25:00 AM / by Stacy Matthews Branch, DVM, PhD posted in CAR-T, Immunotherapy, T Cells

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Scientists discover a new approach to rapidly expand T cells ex-vivo that can be useful for anti-cancer immunotherapeutic approaches.

The development of safe and effective T cell−based anti-cancer immunotherapies is continually developing and have led to some successes. This approach depends on the rapid ex vivo expansion of functional T cells. However, current methods to achieve this are met with a number of challenges that limit the ability to obtain sufficient T cells in less than the several weeks necessary to expand the cells.

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