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Hematopoietic Stem Cell Mutations May Lead to Increased Risk for Leukemia and Heart Disease

Feb 23, 2021 10:03:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Cardiovascular Disease, Stem Cells

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Two teams of scientists have discovered a set of inherited gene variants that can increase the risk of developing mutations in HSC’s in their lifetimes. The mutations can lead to two different age-related disorders: clonal hematopoiesis of indeterminate potential and myeloproliferative neoplasms. 

Advancing age has been associated with an increased risk of various chronic diseases and conditions. Mutations in hematopoietic stem cells increase as people age and may be linked to an increased risk of leukemia and cardiovascular disease. Somatic mutations in hematopoietic stem cells are connected to the development of myeloproliferative neoplasms (MPN) characterized by an excess of red blood cells, leukocytes, and platelets that leads to an increased susceptibility to develop leukemia.

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Stem Cells Working on Matters of the Heart

Apr 9, 2019 10:06:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cardiovascular Disease, heart disease, Stem Cells

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After suffering from a heart attack, patients may eventually have a treatment option which uses their own stem cells to repair and restore heart muscle tissue.

According to the Centers for Disease control, over 600,000 people in the U.S. die yearly from heart disease, and 735,000 Americans have a heart attack each year. Acute myocardial infarction (heart attack) occurs when blood flow to the heart muscle is blocked leading to damage to the heart muscle tissue.  The heart tries to heal after an infarction, but this involves the formation of scar tissue that does not restore adequate function to the heart. The advancement of regenerative medicine using adult stem cells for cardiac tissue repair has the potential to provide a means to repair heart tissue in a way that returns full heart muscle cell function.

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Study of Key Cellular Process in Cardiovascular Disease Now Possible with Stem Cell Research

Feb 14, 2018 10:24:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cardiovascular Disease, stem cell research

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A global leading cause of death is cardiovascular disease (CVD), and this is often linked to a number of abnormalities in the arterial system. Numerous clinical, in vivo, and in vitro studies are ongoing to better understand various forms of CVD and to find ways to combat it. Although studying cells of the cardiovascular system in vitro has led to many discoveries, it is a challenge to study explanted cells because they do not grow well and lose specificity. However, researchers found that a combination of two transcription factors, MYCN and SOX17, can induce and indefinitely expand cultured human arterial endothelial cell precursors that are derived from CD34+ stem cells

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The Role of CD34+ Stem Cells in Treating Cardiovascular Disease

Mar 20, 2017 2:49:36 PM / by Stacy Matthews Branch, DVM, PhD posted in Bone Marrow, Cardiovascular Disease, Cell Therapy, stem cell research, Stem Cell Therapy, Stem Cells

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The leading cause of death for U.S. citizens is cardiovascular disease, which affects nearly a third of the U.S. population. There is an active and dedicated search for effective therapies to address this serious medical issue. The use of immunotherapy approaches for a number of diseases and conditions is continuously gaining momentum. Included in this is the use of CD34+ stem cells from a patients’ own blood (autologously derived) to treat cardiovascular disease. CD34+ is derived from bone marrow and other tissue types. However, CD34+ stems cells are more widely known for their hematopoietic origin.

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CD34+ and CD34+CD133+ Stem Cell Levels Predict Cardiovascular Outcome in Patients With Type 2 Diabetes

Feb 20, 2017 8:00:54 AM / by Stacy Matthews Branch, DVM, PhD posted in Cardiovascular Disease, Stem Cell Therapy, Stem Cells

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Cardiovascular diseases are a leading cause of death worldwide. There are various risk factors for cardiovascular disease such as obesity, physical inactivity, smoking, and diabetes. The risk of cardiovascular disease and stroke in patients with type 2 diabetes is more than twice that of people without diabetes.

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