Researchers find that activated platelets secrete CCL5, which stimulates megakaryocytes to produce more platelets.
Blood platelets play an important role in many physiological conditions that occur in the body. Their main role is to limit bleeding and blood loss by forming clots at sites where the endothelial layer is disrupted. They are formed from fragments of the cytoplasm of megakaryocytic, large bone marrow progenitor cells that release proplatelets into the bloodstream. When conditions such as infections, inflammation or malignancy occur, there is a transient occurrence of a high platelet count. Their blood levels are important. A low platelet level lead to bleeding and too many can result in blood clots, so understanding how their numbers are regulated is important. However, it is still not clear how this occurs – well, until recently.