Blog | HemaCare

Stem Cell Method Sheds Light on Heart Disease

Jul 2, 2018 9:59:00 AM / by Stacy Matthews Branch, DVM, PhD posted in heart disease, stem cells, CD34, cd 34 stem cells

0 Comments

Studying the biological processes that lead to the development of heart disease is essential in the study of preventive and therapeutic approaches to combat the illness.

One in every four deaths in the US is due to heart disease, and the most common type is coronary heart disease caused by arteriosclerosis, a hardening and thickening of the arteries. Studying the biological processes that lead to the development of arterial disease is essential in the study of preventive and therapeutic approaches to combat cardiovascular disease. In vitro methods important for studying disease mechanisms are challenging because explanted endothelial cells can lose their distinctive characteristics.

Read More

Progress in Sickle Cell Cure Research

Mar 26, 2018 10:08:00 AM / by Stacy Matthews Branch, DVM, PhD posted in sickle cell disease, disease-state products, CD34, cd 34 stem cells

0 Comments

The findings of a new study on sickle cell disease may lead to a new era in the approach to treatment.

Sickle cell disease (often referred to as sickle cell anemia) is a group of blood disorders in which the blood cells have an abnormal sickle shape instead of the biconcave disk shape. The sickle-shaped cells have a shorter life span (leading to anemia), but they also block normal blood flow leading to pain and organ dysfunction. There is no cure, and treatments that exist are aimed to control symptoms and related complications.

Read More

Therapeutic Gene Editing in CD34+ Stem Cells from Patients with Fanconi Anemia

Nov 8, 2017 3:38:25 PM / by Stacy Matthews Branch, DVM, PhD posted in cd 34 stem cells, CD34, stem cell gene therapy, stem cells

0 Comments

Gene (or genome) editing refers to various technologies that are used to alter genetic material. This technology is used as a new means to treat diseases including genetic disorders. Fanconi anemia is an inherited disease that affects bone marrow leading to decreased production of all blood cell types. In general, editing of CD34+ (hematopoietic) stem cells have proven more difficult than for fibroblasts or embryonic stem cells. Some advances have been achieved in this regard; however, the efficiency of gene editing for CD34+ stem cells remains less than that possible with lentiviral vectors.

Read More

CD34 Stem Cell−Derived Natural Killer Cells Are Better for Immunotherapy than Peripheral or Cord Blood Natural Killer Cells

May 19, 2017 2:21:35 PM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, cd 34 stem cells, new immunotherapy advances, research, Stem Cell Therapy

0 Comments

Natural killer (NK) cells are immune cells that can be used as a form of immunotherapy and are particularly effective in the treatment of acute myeloid leukemia (AML). NK cells can be obtained from peripheral or cord blood, but with low yields. This limits their use for patients that need multiple treatments. They also have a short survival time and do not proliferate or remain viable after injection into patients. The availability of NK cells for therapy can be enhanced by stimulating their production from hematopoietic (CD 34+) stem cells.

Read More

Patient with Sickle Cell Disease Responds Favorably to Gene Therapy

Apr 11, 2017 11:01:21 AM / by Stacy Matthews Branch, DVM, PhD posted in biomedical research, cd 34 stem cells, Hematopoietic History, research, sickle cell disease, Stem Cell Therapy

0 Comments

Sickle cell disease refers to a group of genetic blood disorders mainly affecting people of African, Mediterranean, Middle Eastern, and Caribbean decent. Those with sickle cell disease carry the abnormal hemoglobin S in their red blood cells due to a mutation of the β-globin gene. Instead of having flexible, disc-shaped red blood cells, affected individuals have characteristic sickle-shaped, more rigid cells that cause disturbances in blood flow and tissue oxygenation.

Read More

Subscribe Here!

Posts by Topic

see all

Recent Posts