Blog | HemaCare

Stem Cell Method Sheds Light on Heart Disease

Jul 2, 2018 9:59:00 AM / by Stacy Matthews Branch, DVM, PhD posted in cd 34 stem cells, CD34, heart disease, stem cells

0 Comments

Studying the biological processes that lead to the development of heart disease is essential in the study of preventive and therapeutic approaches to combat the illness.

One in every four deaths in the US is due to heart disease, and the most common type is coronary heart disease caused by arteriosclerosis, a hardening and thickening of the arteries. Studying the biological processes that lead to the development of arterial disease is essential in the study of preventive and therapeutic approaches to combat cardiovascular disease. In vitro methods important for studying disease mechanisms are challenging because explanted endothelial cells can lose their distinctive characteristics.

Read More

Progress in Sickle Cell Cure Research

Mar 26, 2018 10:08:00 AM / by Stacy Matthews Branch, DVM, PhD posted in cd 34 stem cells, CD34, disease-state products, sickle cell disease

0 Comments

The findings of a new study on sickle cell disease may lead to a new era in the approach to treatment.

Sickle cell disease (often referred to as sickle cell anemia) is a group of blood disorders in which the blood cells have an abnormal sickle shape instead of the biconcave disk shape. The sickle-shaped cells have a shorter life span (leading to anemia), but they also block normal blood flow leading to pain and organ dysfunction. There is no cure, and treatments that exist are aimed to control symptoms and related complications.

Read More

Therapeutic Gene Editing in CD34+ Stem Cells from Patients with Fanconi Anemia

Nov 8, 2017 3:38:25 PM / by Stacy Matthews Branch, DVM, PhD posted in cd 34 stem cells, CD34, stem cell gene therapy, stem cells

0 Comments

Gene (or genome) editing refers to various technologies that are used to alter genetic material. This technology is used as a new means to treat diseases including genetic disorders. Fanconi anemia is an inherited disease that affects bone marrow leading to decreased production of all blood cell types. In general, editing of CD34+ (hematopoietic) stem cells have proven more difficult than for fibroblasts or embryonic stem cells. Some advances have been achieved in this regard; however, the efficiency of gene editing for CD34+ stem cells remains less than that possible with lentiviral vectors.

Read More

Use of Cord Blood CD34+ Stem Cells for Large-Scale Production of Human Neutrophils

Aug 24, 2017 3:12:38 PM / by Stacy Matthews Branch, DVM, PhD posted in CD34, neutrophil, neutrophils, stem cell research, Stem Cell Therapy, stem cells

0 Comments

Severe and prolonged neutropenia is a common consequence of cancer chemotherapy and is associated with an increased risk of severe infections. Transfusion of donor neutrophils is a viable option to combat this, but obtaining matched donors is a dilemma. There are pharmacologic interventions aimed at shortening the duration of neutropenia and combatting infection; however, infection risk remains high due to a lack of response to these treatments in many patients.

Read More

Improvement in Diastolic Function After CD34+ Cell Transplantation in Patients with Nonischemic Dilated Cardiomyopathy

Apr 13, 2017 9:42:42 AM / by Stacy Matthews Branch, DVM, PhD posted in biomedical research, CD34, research, stem cell research, Stem Cell Therapy

0 Comments

Dilated cardiomyopathy occurs when the heart muscle stretches and becomes weakened, leading to less efficient pumping of the blood throughout the body. It is the most common form of non-ischemic cardiomyopathy (not due to coronary artery disease). Dilated cardiomyopathy may be associated with damage to the heart muscle from a variety of causes such as inflammation, infections, and toxic substances. Diastolic dysfunction seen in patients with dilated cardiomyopathy refers to insufficient relaxation and filling of the ventricles during the second part of the heart-pumping phase (leading to increased pressure in the ventricles).

Read More

Subscribe Here!

Posts by Topic

see all

Recent Posts