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DARTs-Targeting the Elimination of HIV-Infection

Sep 7, 2016 3:42:11 PM / by Stacy Matthews Branch, DVM, PhD posted in CD4, CD4+ helper T cells, cytotoxic T cells, HIV, research

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Available therapies used to prevent the development of AIDS in HIV-infected individuals work by reducing the level of infection, but do not completely destroy the infection. A persistent source of HIV-infected cells remains in HIV-infected individuals despite being on long-term antiviral therapy. This causes ongoing inflammation and immune system activation, putting these individuals at risk for developing non-AIDS diseases and conditions. Given the increased risk of health with the persistent presence of HIV-infected cells, new treatment approaches are needed that will completely eliminate or kill the HIV-infected cells, removing the source (reservoir) of these cells.

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