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Cell Cryopreservation: Key to Optimal Cell Therapy Development and Application

Jan 4, 2018 10:35:00 AM / by Stacy Matthews Branch, DVM, PhD posted in cryopreservation, cell therapy

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Cryopreservation of therapeutic cells allows the long-term storage of functional cells and prevents degradative processes. Fresh cells are also used for cellular therapy approaches; however, there are many circumstances that make the availability of cryopreserved cells a must for repeated and on-hand use of cells. Cell cryopreservation provides a reliable stock of cells, which reduces the variability of cell therapy product. This translates to a more standardized product that can be used on a larger scale and without constraints on optimal availability for clinical use. 

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The Role of CD34+ Stem Cells in Treating Cardiovascular Disease

Mar 20, 2017 2:49:36 PM / by Stacy Matthews Branch, DVM, PhD posted in Bone marrow, bone marrow, Cardiovascular Disease, CD34, cell therapy, stem cell research, stem cell therapy, Stem Cell Therapy, stem cells

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The leading cause of death for U.S. citizens is cardiovascular disease, which affects nearly a third of the U.S. population. There is an active and dedicated search for effective therapies to address this serious medical issue. The use of immunotherapy approaches for a number of diseases and conditions is continuously gaining momentum. Included in this is the use of CD34+ stem cells from a patients’ own blood (autologously derived) to treat cardiovascular disease. CD34+ is derived from bone marrow and other tissue types. However, CD34+ stems cells are more widely known for their hematopoietic origin.

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Leukopak Versus Buffy Coat

Feb 27, 2017 8:53:23 AM / by Stacy Matthews Branch, DVM, PhD posted in buffy coat, cell therapy, Dendritic cells, leukapharesis procedures, leukopaks, stem cell research

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Leukapheresis is a procedure to separate white bloods cells (including dendritic and progenitor cells) from a blood sample. Products obtained from leukapharesis procedures, leukopaks, are regularly used in the research setting. They are also used for cell therapy process development and clinically for certain treatment procedures for blood disorders. Another way to obtain white blood cells and platelets is to obtain them from the buffy coat.

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Stroke Patient Walks Again After Experimental Stem Cell Therapy

Jan 18, 2017 12:00:18 AM / by Stacy Matthews Branch, DVM, PhD posted in Bone marrow, bone marrow, cell therapy, stem cell research, stem cell therapy, Stem Cell Therapy, stem cell transplantation, stem cells

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Nearly 7 million people in the U.S. (about 2% of the total U.S. population) suffer some level of stroke-related brain damage and related health problems. Studies in animals suggest that cell-based therapies can improve post-stroke outcomes. To determine the safety of cell-therapy approaches in humans, researchers from Stanford University conducted a clinical trial to study the safety of a procedure to transplant donor stem cells in the brains of patients with chronic stroke. 

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PBMCs: A More Personal Approach To Cell Therapy

Aug 17, 2016 4:35:46 PM / by Stacy Matthews Branch, DVM, PhD posted in cell therapy, Peripheral blood cells, peripheral blood mononuclear cells, research, T cells

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Peripheral blood mononuclear cells (PBMCs) are peripheral blood cells containing a round nucleus. Examples of these types of cells include the various types of lymphocytes (including T cells) and monocytes. These are different from other blood cells that contain multi-lobed nuclei (e.g., neutrophils and eosinophils) and those that have no nucleus such as platelets and red blood cells (erythrocytes).

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