In the first part, we outlined the steps in differentiation of pluripotent stem cells to pancreatic β cells. Here, we discuss how patient-specific pluripotent stem cells provide better therapeutic options.
Management of diabetes is a major health concern and recent research in pluripotent stem cells shows promise in effective therapy. We provide a comprehensive outlook in our three part series.
While generating induced Pluripotent Stem Cells (iPSCs) may have caused researchers some stress over the years, a new finding suggests that putting some stress on their cells instead could make their lives surprisingly easier. It turns out that external stressors like physical damage or low pH can lead a cell to have stem cell properties including pluripotency, making the process of cellular reprogramming faster and more efficient than ever before.
Reprogramming peripheral blood cells is performed via introduction of key factors by viral vectors. New vectors make this process safer for use in humans.
Cellular reprogramming of peripheral blood cells is opening the door to new scientific advances. In Part I of this series, we discussed why peripheral blood cells are a prime source for cells to use for iPSC induction. Here we discuss the critical factors responsible for cellular reprogramming of peripheral blood cells.