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Exocytosis is Equally Impaired in Chediak–Higashi Syndrome Natural Killer and Cytotoxic T Cells Despite Differences in Granule Morphology

May 22, 2017 11:30:52 AM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, Chediak–Higashi syndrome, Cytotoxic T Cells, research


Chediak–Higashi syndrome is caused by a genetic mutation resulting in enlargement of lysosomes (cell organelles containing digestive enzymes). People with Chediak–Higashi syndrome have albinism of the eyes and skin and can develop a life-threatening overactive inflammatory syndrome. The cytotoxic function of natural killer (NK) and cytotoxic T cells is impaired in patients with Chediak–Higashi syndrome. Given the devastating nature of the inflammatory syndrome that can develop, there is a clinical benefit and need for the ability to predict the clinical outcome of patients with Chediak–Higashi syndrome.

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