Blog | HemaCare

When It's Really Bad: Bone Marrow Transplant for Crohn's Disease?

Oct 26, 2015 1:00:00 PM / by Maria posted in Bone Marrow, bone marrow transplantation, chemotherapy, graft versus host disease, research

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Some patients with Crohn's disease don't respond to treatment, and life is extremely impaired. Do drastic times call for drastic measures?

Millions of people worldwide have Crohn's disease, a gastrointestinal disorder that causes diarrhea, cramps, and fatigue, among other symptoms throughout the body. The exact cause of Crohn's disease remains a mystery, but scientists believe that patients are genetically predisposed to Crohn's disease, and in particular, a patient's immune system is in play.

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Trichostatin A: A Better Way to Target Chronic Lymphocytic Leukemia Cells?

Oct 27, 2014 1:00:02 PM / by Shweta posted in B Cells, apoptosis, Bone Marrow, Cancer, Cancer Immunology, Cell Therapy, chemotherapy, chronic lymphocytic leukemia, CLL, disease-state cells, Independent validation, Innovation, PBMCs, Peripheral blood cells, research, white blood cells

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Scientists have shown that trichostatin A could be a potent apoptosis inducer to target chronic lymphocytic leukemia cells.

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Outsmarting B cells in Chronic Lymphocytic Leukemia

Oct 15, 2014 1:00:47 PM / by Daisy posted in chemotherapy, chronic lymphocytic leukemia, CLL, research

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Chronic lymphocytic leukemia (CLL) is a type of cancer of the peripheral blood mononuclear cells (PBMC) with massive unregulated production of B cells.

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Engineering Hematopoietic Stem Cells for a One-Two Punch of Cancer Immunotherapy

Mar 26, 2014 6:16:13 AM / by Maria posted in PBCs, Cancer, Cancer Immunology, cancer immunotherapy, Cell Therapy, chemotherapy, drug development, hematopoietic stem cells, HSCs, Immunotherapy, Innovation, leukemia, lymphoma, Peripheral blood cells, research, stem cell therapy, Stem Cells, T Cells

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In Part I of this series we introduced T cell based immunotherapy and in Part II we discussed how chimeric antigen receptors (CARs) expressing T cells can be even more potent. In Part III below, we expand this concept further by covering hematopoetic stem cells and additional ways they can be engineered for promising immunotherapy of cancer and leukemia.

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CAR-Expressing T Cells: Driving the Express Track to Cancer Immunity

Mar 19, 2014 6:10:31 AM / by Maria posted in Cancer, Cancer Immunology, cancer immunotherapy, Cell Therapy, chemotherapy, drug development, hematopoietic stem cells, HSCs, Immunotherapy, Innovation, leukemia, lymphoma, research, T Cells, T lymphocytes, tumor, tumor cells

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In the first part of this series we introduced the concept of cell-based immunotherapy with T cell transplants. Next, we describe an even more potent approach to cancer treatment with T cells that are engineered to express anti-tumor molecules or cell surface tumor-identifying killer receptors. The latter of which are called chimeric antigen receptors, or CARs.

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