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Developing Antibody Drugs Against B-cells

Jan 11, 2016 1:00:44 PM / by Daisy posted in Cancer Immunology, chronic lymphocytic leukemia, clinical trial, CLL, obinutuzumab, research, rituximab

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The success of rituximab as an antibody drug targeting B-cells has led to the development of obinutuzumab – a similar, third-generation drug

Chronic lymphocytic leukemia (CLL) is a B-cell disease that is currently incurable. Combining targeted drugs has improved overall survival. However, not all patients benefit, because B-cells can harness any of several mechanisms to gain unrestricted proliferative capacity (see here).

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Trichostatin A: A Better Way to Target Chronic Lymphocytic Leukemia Cells?

Oct 27, 2014 1:00:02 PM / by Shweta posted in apoptosis, B cells, Bone marrow, cancer, Cancer Immunology, cell therapy, chemotherapy, chronic lymphocytic leukemia, CLL, disease-state cells, Independent validation, Innovation, PBMCs, Peripheral blood cells, research, white blood cells

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Scientists have shown that trichostatin A could be a potent apoptosis inducer to target chronic lymphocytic leukemia cells.

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Outsmarting B cells in Chronic Lymphocytic Leukemia

Oct 15, 2014 1:00:47 PM / by Daisy posted in chemotherapy, chronic lymphocytic leukemia, CLL, research

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Chronic lymphocytic leukemia (CLL) is a type of cancer of the peripheral blood mononuclear cells (PBMC) with massive unregulated production of B cells.

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