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Translatable Research on Stem Cells ... from Fido and Fluffy?

Mar 9, 2016 1:00:48 PM / by Maria posted in arthritis, Cancer, clinical trials, research, Stem Cell Therapy, Stem Cells

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You can only learn so much from laboratory mice. Trials of stem cells conducted in our four-legged friends may serve as a bridge to human studies.

A staple in labs across the world, laboratory rodents are genetically homogenous, closely monitored, and are kept in standard, controllable environments -- and that's a problem. In the human real world, people are genetically different, have various diets and habits, and live in diverse environments. What's more, many times disease is induced in these animals, whereas in humans diseases are rarely planned and may have more than one cause. It's not very surprising that so many promising preclinical experiments do not pan out in human clinical trials. The cost of these failures is sky high, for companies, patients, and society.

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IL-21 Strikes Twice: a Two-in-One Therapy for Aggressive non-Hodgkin Lymphoma

Dec 14, 2015 1:00:07 PM / by Dalia Gaddis posted in IL-21, Cancer Immunology, cancer immunotherapy, clinical trials, non-hodgkin lymphoma, research, T Cells

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IL-21 has dual anti-tumor effects in mantle cell lymphoma, offering new hopes for a better therapy.

Since the signing of the National Cancer Act in 1971, the medical field has achieved significant progress in finding cures for certain types of cancer. Therapies against breast cancer and childhood leukemia have undergone major advances in the past four decades. However, when it comes to non-Hodgkin lymphoma (NHL), the struggle is still loud and clear. More than 60,000 Americans are diagnosed with NHL each year and the current estimates are 30% of these cases will not survive the disease.1

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Epigenetic Therapy May be a Boon for Aggressive Leukemia

Aug 24, 2015 1:00:27 PM / by Shweta posted in Cancer, Cancer Immunology, cancer immunotherapy, clinical trials, Innovation, leukemia, research, T lymphocytes, white blood cells

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New discovery can make an existing leukemia treatment more effective

Prolymphocytic leukemia (PLL) is a rare and aggressive form of malignancy characterized by marked lymphocytosis and splenomegaly. PLL represents only 2% of all chronic lymphoid leukemias in adults over the age of 30. Most patients with PLL shows involvement of the peripheral blood, bone marrow, lymph nodes, liver, and spleen. In addition, skin infiltration and serious effusions may also occur at rates of approximately 25 and 15 percent, respectively.

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FDA Provides Guidance for Early Stage Trials of Gene and Cellular Therapy

Jul 15, 2015 1:00:47 PM / by Maria posted in FDA, clinical trials, research, Stem Cell Therapy, Stem Cells

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Gene and cellular therapy is different from the drugs that have come before -- and so are the dangers. Guidance from the FDA is available to avoid pitfalls.

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"Magic" Mushrooms to Cast Away Prostate Cancer?

Jun 3, 2015 1:00:02 PM / by Maria posted in Cancer Immunology, clinical trials, interleukins, myeloid-derived suppressor cells, natural products, research

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For some patients in a clinical trial, mushroom powder may have reversed a troubling indication of prostate cancer reoccurrence.

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