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Human Adult Peripheral and Umbilical Cord Blood Platelet-Rich Plasma Have Similar Effects on Skin Healing Processes

Aug 28, 2017 9:31:22 AM / by Stacy Matthews Branch, DVM, PhD posted in cord blood, platelet-rich plasma, research

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Regrowth and healing of skin after severe traumas such as burns and other extensive skin damage are significant medical challenges and depend on complex skin regeneration mechanisms. Skin and other tissue regeneration processes start with platelet degranulation and clotting that are associated with the release of a number of factors including clotting factors and cytokines. Skin tissue regeneration also relies on the action of growth factors. Platelet-rich plasma (PRP) is beneficial for tissue regeneration processes because platelets promote the secretion of growth factors that are essential in wound healing.

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Cord Blood Regulatory T cells Provide New Hope for Transplant Patients

Jul 20, 2016 1:00:08 PM / by Dalia Gaddis posted in Graft, cancer, cord blood, Immune suppression, immunotherapy, Innovation, research

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A clinical trial shows that cord blood regulatory T cells help reduce GVHD in high-risk blood malignancies.

One of the worst adverse effects of bone marrow or stem cell transplant is graft versus host disease. Side effects can range from rashes to a complete destruction of vital organs such as kidneys or liver. Thanks to regulatory T cells from cord blood, transplant patients may have a better therapy option.

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Scientists Find A New Way to Expand Cord Blood Stem Cells

Jun 8, 2016 1:00:46 PM / by Karina Palomares posted in cord blood, hematopoietic stem cell transplantation, hematopoietic stem cells, stem cells, Uncategorized

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McMaster University researchers discovered how an RNA-binding protein regulates self-renewal capacity of cord blood stem cells.

Human umbilical cord blood was once discarded as medical waste, but is now known to be a rich source of hematopoietic stem cells (HSCs). Cord blood stem cells can be potentially used in the treatment of various diseases of the blood, including cancer and other genetic disorders. However, as with other HSC sources, the total number of functional and engraftable stem cells still remains the limiting variable that strongly impacts transplantation success. Identifying methods for robust expansion of HSCs is necessary to generate an inexhaustible source of stem cells for use in regenerative medicine.

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Science Beneath the Successful Cord Blood Banking

Aug 27, 2014 12:11:33 PM / by Shweta posted in Hematopoietic History, cord blood, cord blood banking, hematopoietic stem cells, Innovation, research, stem cells, UCB, white blood cells

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Safe cord blood banking: A stock for baby’s long term health

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Will T Cells Be the Future Basis of Cancer Therapy?

Mar 12, 2014 6:00:07 AM / by Maria posted in PBCs, antibodies, Bone marrow, cancer, Cancer Immunology, cell therapy, chemotherapy, cord blood, drug development, Innovation, Peripheral blood cells, peripheral blood mononuclear cells, research, stem cell therapy, stem cells, T cells, T lymphocytes, tumor

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Recent data suggest that the average person has about a 40% chance of developing cancer at some point in his or her lifetime. [1] If those statistics are not frightening enough, let’s talk treatment: chemotherapy, radiation, surgery, chemical-based drug therapy, or a combination of the above. And don’t forget the various side effects of cancer therapy, many of which are a result of the destruction of crucial adult stem cells in the body. Because of this, stem cell transplants have been performed with fresh stem cells originating from bone marrow, peripheral blood, or cord blood to help replenish a patient’s hematopoietic system.

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