Blog | HemaCare

Improving the Efficiency of Clinical Gene Therapy

Jul 23, 2018 10:09:00 AM / by Nancy Andon, MSc posted in Gene Therapy, Bone Marrow, Cord Blood, Stem Cells

0 Comments

An independent study [1] cites using HemaCare-sourced human cord blood, bone marrow, and mobilized peripheral blood as the starting material in a new strategy for more efficient genetic modification of human stem cells.

The study is based at the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy. Researchers there have been looking into ways to make gene transduction, which is used to introduce an edited copy of a human gene into stem cells, more efficient. The new strategy is part of their goal to improve the potency and long-term engraftment of stem cells used for gene therapy in the clinic.

Read More

Human Adult Peripheral and Umbilical Cord Blood Platelet-Rich Plasma Have Similar Effects on Skin Healing Processes

Aug 28, 2017 9:31:22 AM / by Stacy Matthews Branch, DVM, PhD posted in Cord Blood, Plasma, Basic Research

0 Comments

Regrowth and healing of skin after severe traumas such as burns and other extensive skin damage are significant medical challenges and depend on complex skin regeneration mechanisms. Skin and other tissue regeneration processes start with platelet degranulation and clotting that are associated with the release of a number of factors including clotting factors and cytokines. Skin tissue regeneration also relies on the action of growth factors. Platelet-rich plasma (PRP) is beneficial for tissue regeneration processes because platelets promote the secretion of growth factors that are essential in wound healing.

Read More

Bone-forming cells enhance production of human cord blood cells

Oct 26, 2016 1:28:46 PM / by Stacy Matthews Branch, DVM, PhD posted in Bone Marrow, Cord Blood, Stem Cells

0 Comments

Human cord blood is a critical source of cells used to treat blood disorders. However, this source contains low numbers of cells that make successful transplants more difficult. The bone marrow of adults contain blood-forming stem cells that are self-renewing, can grow well, and can become different types of mature blood cells. Osteoblasts (bone-forming cells) are involved in the production of hematopoietic (blood-forming) stem and progenitor cells (HSPCs). Studies have shown that osteoblasts release extracellular vesicles (EVs), small structures within cells that contain various molecules and factors for various cellular functions. The EVs from osteoblasts play a role in maintaining a source of HSPCs needed for hematopoiesis (blood cell formation).

Read More

New Research Shows Hope for Cancer Patients

Oct 12, 2016 1:00:52 AM / by Stacy Matthews Branch, DVM, PhD posted in Bone Marrow, Cancer, Cord Blood

0 Comments

 

F or cancers such as leukemia (cancer of the white blood cells), chemotherapy followed by stem-cell transplantation to repopulate with healthy cells is the treatment of choice. There are various sources of stem cells including bone marrow , circulating blood, and umbilical cord blood. Researchers reviewed hundreds of cases of leukemia as well as other blood disorders. They found that those patients who received stem cells from human cord blood , had survival rates that were similar to or higher than those who received other types of stem cell transplants.
Read More

Cord Blood Regulatory T cells Provide New Hope for Transplant Patients

Jul 20, 2016 1:00:08 PM / by Dalia Gaddis posted in Cord Blood, Regulatory T Cells

0 Comments

A clinical trial shows that cord blood regulatory T cells help reduce GVHD in high-risk blood malignancies.

One of the worst adverse effects of bone marrow or stem cell transplant is graft versus host disease. Side effects can range from rashes to a complete destruction of vital organs such as kidneys or liver. Thanks to regulatory T cells from cord blood, transplant patients may have a better therapy option.

Read More

      Subscribe Here!

      Posts by Topic

      see all

      Recent Posts