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Characterization of T Cell Subsets in Adult Minimal Change Disease

Nov 22, 2017 8:00:42 AM / by Stacy Matthews Branch, DVM, PhD posted in Cytotoxic T Cells, T Cells

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Minimal change disease (MCD) is a kidney disease characterized by pathology in the glomeruli. The disease has its name because changes associated with it can only be seen via electron microscopy. The effects on the glomeruli lead to its increase in permeability and subsequent severe loss of proteins in the urine. Immunological changes in the kidney tissue are thought to promote the development of MCD. Research studies have suggested that abnormalities in Foxp3 T regulatory (Treg) cells, which control immune homeostasis, are involved in MCD pathogenesis.

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CD5-Marked Dendritic Cells Are Associated with Inflammatory Skin Disease

Nov 13, 2017 9:11:26 AM / by Stacy Matthews Branch, DVM, PhD posted in Cytotoxic T Cells, Dendritic Cells

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Dendritic cells are powerful antigen-presenting cells of the immune system. Subsets of dendritic cells are distinguished by distinct cell surface markers. These markers are responsible for the differences in dendritic cell subset functions. Studies show that specific types of dendritic cells are associated with the development of inflammatory skin diseases such as psoriasis. The specific dendritic cell associated with the cytotoxic T cell response remains unknown. Therefore, research was conducted that examined human skin dendritic cell populations.

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Structural Differences Associated with the Cytotoxic T-cell Response to an Immunodominant Epitope of the Influenza A Virus

Nov 6, 2017 1:23:01 PM / by Stacy Matthews Branch, DVM, PhD posted in Cytotoxic T Cells

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The influenza A virus (IAV) is the cause of yearly seasonal flu epidemics and is eliminated by CD8+ cytotoxic T cells. Recognition of infected cells is mediated by T cell receptors composed of two (a and b) glycoprotein chains. These receptors bind viral peptides presented by major histocompatibility complex (MHC) class I molecules on infected cells. Cytotoxic T cell receptors that recognize GILGFVFTL (GIL), the immunodominant epitope of IAV, are produced in people who express the MHC class I molecule HLA-A2.

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Combination of Cytotoxic T cells with Cytarabine Synergistically Induces Leukemia cell Apoptosis by Inhibition of Bcl-2 Expression

Oct 5, 2017 2:37:03 PM / by Stacy Matthews Branch, DVM, PhD posted in Cytotoxic T Cells

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Acute myeloid leukemia (AML) is a cancer originating from cells of the bone marrow and remains difficult to cure due to relapses. There have been significant advances in the development of immunotherapeutic approaches to various types of cancer. Immunotherapy stimulates the patient’s immune system to destroy cancer cells without the harmful adverse effects seen with conventional chemotherapy.

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Cytotoxic T Cell Impairment is Not a Feature of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Aug 30, 2017 8:30:02 AM / by Stacy Matthews Branch, DVM, PhD posted in Cytotoxic T Cells

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Myalgic encephalomyelitis, also referred to as chronic fatigue syndrome (ME/CFS), is a debilitating condition with unknown etiology that is characterized by excessive and persistent fatigue with physical or mental exertion, often accompanied by flu-like symptoms, and not relieved by rest. Previous clinical studies suggest that infections caused by intracellular pathogens, such as Epstein-Barr virus, may elicit ME/CFS. Therefore, predisposition to the development of ME/CFS may be associated with an impairment of the immune system.

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