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Personalized Vaccine Fights Ovarian Cancer

Jul 9, 2018 9:57:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Dendritic cells, dendritic cell vaccine, T cells, immunotherapy

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Ovarian cancer, while common, is challenging to treat, but a new study is looking into an immunotherapeutic approach using a vaccine from dendritic cells.

Ovarian cancer is the fifth leading cause of cancer death overall in women, but is the leading cause of death due to cancer of the female reproductive system. Ovarian cancer continues to be a challenge to treat, remission is difficult to achieve, and recurrence is common. The treatment approaches used or being studied involve chemotherapy, targeted therapy (to limit damage to normal cells), and immunotherapy. The study of immunotherapeutic approaches is ongoing in order to limit adverse effects in patients and to spare normal tissue from the toxicity seen with chemotherapy. To this end, researchers recently studied an immunotherapeutic approach using a vaccine derived from dendritic cells.

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New Improvements for Prostate Cancer Immunotherapy

Jun 25, 2018 10:08:00 AM / by Stacy Matthews Branch, DVM, PhD posted in new immunotherapy advances, immunotherapy, cancer treatment, Dendritic cells, dendritic cell vaccine

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Immunotherapy is a highly studied treatment for cancers, and is now being considered for the treatment of prostate cancer, the most common cancer diagnosis for U.S. men.

Prostate cancer is the most common cancer diagnosis for men in the U.S. and a leading cause of cancer-related death. A heavily studied cancer treatment approach is immunotherapy and is increasingly being investigated for the treatment of prostate cancer. Although results of immunotherapy trials for prostate cancer present many challenges (relapse and development of resistance in some patients), they still show potential therapeutic promise.

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Dendritic Cells Change Game for Immunotherapy for Cancer Patients

May 7, 2018 10:07:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Dendritic cells, Dendritic Cell Immunotherapy, immunotherapy, dendritic cell vaccine

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Further development and wider use of dendritic cell-based anticancer vaccines has the potential to significantly increase cancer survival rates and improve the quality of life and function with fewer adverse effects.

Anticancer therapy using the patient’s own immune cells is an ever-growing area of cancer research that supports personalized medical efforts. This approach in immunotherapy provides specific results that can spare normal tissue and considerably decrease adverse side effects. The use of dendritic cells, powerful antigen-presenting cells of the immune system, is extensively studied. Positive gains have been realized in this arena and are changing the face of cancer therapy.

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New Progress in Immunotherapy Strategies

Apr 23, 2018 10:02:00 AM / by Stacy Matthews Branch, DVM, PhD posted in immunotherapy, CAR T cells, cancer treatment, Dendritic cells, dendritic cell vaccine

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State-of-the-art immunotherapies may show great promise in the future for cancer treatment.

Immunotherapy research results show that cancer treatment may need a combination approach. Dr. Andrew S. Chi, the chief of neuro-oncology and the codirector of the Brain Tumor Center at NYU Langone, weighed in on the state of developed immunotherapy approaches. A number of strategies involve increasing T-cell activation against tumors by the use of checkpoint inhibitors (that block proteins that inhibit immune system attack of cancer cells). Dr. Chi points out that combinations of immune checkpoint inhibitors may be more effective. 

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Improved Cancer Immunotherapy Possible with Dendritic Cell Vaccines

Apr 2, 2018 10:11:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Dendritic cells, dendritic cell vaccine

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Personalized dendritic cell vaccines have continued to show success with the treatment of certain cancers. 

Dendritic cell vaccines are increasingly showing success in the treatment of certain cancers. Dendritic cells are antigen-presenting cells that process antigens then present them to T cells. In the personalized approach to using dendritic cells vaccines, cells are obtained from the patient, exposed or loaded with cancer antigens, and grown. The resulting antigen-loaded dendritic cells are injected back into the patient, where the dendritic cells can elicit the anti-cancer immune response of T cells.

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