Blog | HemaCare

What Are the Benefits to Using Disease State Samples?

Mar 19, 2018 10:18:00 AM / by Stacy Matthews Branch, DVM, PhD posted in disease cells, disease-state cells

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Disease state specimens boost the ability to achieve scientific advances and characterize the cellular and molecular features of a disease and its progression.

Progress in personalized medicine continues as more methods are developed to enhance diagnostic and prognostic efforts. Molecular technologies allow the identification of factors that can be used for early disease diagnosis, prediction of disease susceptibility, monitor disease development, determine treatment effectiveness, and to determine a patient’s disease prognosis. The availability of disease state specimens has bolstered the ability to achieve these advances and to characterize the cellular and molecular features of a disease and its progression.

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Stem Cells and Gene Editing Technology Together Create a Mini-Kidney in the Lab

Nov 30, 2015 1:00:54 PM / by Shweta posted in disease modeling, disease-state cells, induced pluripotent stem cells, Innovation, Regenerative Medicine, Stem Cells

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Gene editing technology along with stem cells helped scientists develop a miniature scale kidney

In the past, researchers already developed complex kidney structures using stem cells. Now, the main aim of kidney tissue engineering is to develop new therapies to repair kidney damage and thus reduce the need for dialysis and transplantation. Recently, scientists at University of Washington in collaboration with Brigham and Women's Hospital and Harvard Stem Cell Institute (HSCI) have grown mini-kidneys in the laboratory [1]. The ex-vivo kidney could be used to study abnormalities in kidney development, chronic kidney disease, and the effects of toxic drugs on acute and chronic kidney conditions.

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Novel iPSC Platform to Study Host-Pathogen Interaction

Apr 29, 2015 1:00:10 PM / by Shweta posted in drug screening, malaria, cellular reprogramming, disease-state cells, Drug Discovery, induced pluripotent stem cells, Innovation, Stem Cells

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iPSC technology helps scientists model liver-stage malaria in a dish

Malaria is a parasitic disease which kills millions of lives worldwide. The life cycle of the parasite revolves between a mosquito vector and a human host. Malaria is transmitted when Anopheles mosquitoes bite a human being and release hundreds of sporozoites into the bloodstream of the host. After entering into the bloodstream, parasites migrate to the liver, where they can either remain dormant or initiate an asexual multiplication cycle to produce thousands of merozoites. The newly formed merozoites attack red blood cells and further initiate the asexual replication cycle. Some of the merozoites differentiate into male and female gametocytes, which are the only parasite form that can be transmitted from humans to the mosquito vector.

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Trichostatin A: A Better Way to Target Chronic Lymphocytic Leukemia Cells?

Oct 27, 2014 1:00:02 PM / by Shweta posted in B Cells, apoptosis, Bone Marrow, Cancer, Cancer Immunology, Cell Therapy, chemotherapy, chronic lymphocytic leukemia, CLL, disease-state cells, Independent validation, Innovation, PBMCs, Peripheral blood cells, research, white blood cells

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Scientists have shown that trichostatin A could be a potent apoptosis inducer to target chronic lymphocytic leukemia cells.

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Efficient Way to Generate iPSCs for the Treatment of Multiple Sclerosis

Oct 13, 2014 1:00:01 PM / by Shweta posted in disease-state cells, Independent validation, induced pluripotent stem cells, Innovation, iPSCs, Regenerative Medicine, research, stem cell therapy, Stem Cells, tissue engineering

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Scientists have developed an accelerated protocol to generate functional oligodendrocytes for the treatment of multiple sclerosis

In one of our previous blogs we have described that Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by brain inflammation, which arises when the nervous system is attacked by the body’s own immune cells. MS can develop because of viral infection, genetic defects or environmental factors. As yet, the exact etiology of the disease is unfortunately unknown.

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