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Treatment of Fibromyalgia as an Inflammatory Disease

Aug 20, 2018 10:15:00 AM / by Stacy Matthews Branch, DVM, PhD posted in cytokine release syndrome, disease state primary cells, cytokines, cytokine release

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Rheumatologists are recognizing the inflammatory component of fibromyalgia and that has led to studies using disease state primary cells to determine the best treatment approaches.

Fibromyalgia is a chronic condition that is commonly considered a neurologic problem with multifocal pain as an important feature of the disease. However, rheumatologists are recognizing the inflammatory component of fibromyalgia and that pain my not be the primary feature of the condition. Other significant aspects of fibromyalgia are fatigue, sleep disorders, and cognitive impairments. Results of studies in patients with fibromyalgia suggest that excessive cytokine release may be the central cause of the development and symptomology of fibromyalgia.

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Increased Programmed Cell Death in Peripheral Blood Mononuclear Cells from Patients with Hepatitis C Is Linked to Impaired Cytokine Secretion

Apr 13, 2017 9:27:12 AM / by Stacy Matthews Branch, DVM, PhD posted in Dendritic Cells, disease state primary cells, peripheral blood mononuclear cells, research

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Hepatitis C is a viral infection that affects over 3 million people in the U.S. and over 130 million people globally. It can cause acute and chronic liver infections, and those with acute infections usually do not have symptoms or know that they are infected. Acute cases often clear spontaneously without treatment; however, the infection can progress to chronic hepatitis that leads to liver cirrhosis or carcinoma. Immune responses can play important roles in hepatitis C infection and whether it develops into the chronic form. Scientists have found connections between the hepatitis C virus and peripheral blood mononuclear cells, which may play roles in clearing the virus. Alterations in peripheral blood mononuclear cells are thought to be linked to hepatitis C virus infection, but the mechanisms are not fully understood.

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