Blog | HemaCare

The Changing Landscape of Clinical Approval

Aug 27, 2019 10:04:00 AM / by Nancy Andon, MSc posted in Gene Therapy, Cell Therapy, Drug Discovery

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HemaCare is pleased to announce the publication of our latest article [1] in the journal International Clinical Trials (ICT). The paper, entitled “The Landscape of Clinical Approval” describes how changes in the clinical drug approval process are impacting starting material suppliers, and what suppliers are doing to meet increased demands.

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Stem Cell Models for Alzheimer’s Disease Enable Drug Discovery and Development

Feb 3, 2016 1:00:37 PM / by Karina Palomares posted in Drug Discovery, Stem Cells

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Scientists evaluate new treatments of Alzheimer’s disease on neurons derived from iPSCs from patients.

Alzheimer’s disease is the leading cause of dementia, and has affected approximately 48 million people worldwide. Despite decades of research, we have yet to come up with a successful treatment. One major challenge in drug development for neurological diseases is access to a clinically relevant disease model. As stated in a recent WSJ article, results from animal testing often do not predict well what will happen in humans [1].  As a result, many promising drug candidates have been removed from further development because of safety concerns or lack of efficacy.

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Wasp Venom Peptide Targets Cancer Cell Membranes -- Selectively

Nov 2, 2015 1:00:04 PM / by Maria posted in Drug Discovery, natural products, research

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Research with an insect peptide challenges the popular belief that cancer cell membranes don't make good drug targets.

Cell membranes could use a little more respect. No one doubts that the inner machinery of cells is fascinating in its complexity, but membranes themselves are often viewed as rather boring containers that are pretty much the same no matter where you look. But membranes are actually highly complex structures consisting of hundreds of different lipids and proteins, often varying in composition among cell types. Still, even many cell biologists have perhaps not realized the implications this diversity could have for drug discovery.

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Novel iPSC Platform to Study Host-Pathogen Interaction

Apr 29, 2015 1:00:10 PM / by Shweta posted in drug screening, malaria, cellular reprogramming, disease-state cells, Drug Discovery, induced pluripotent stem cells, Innovation, Stem Cells

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iPSC technology helps scientists model liver-stage malaria in a dish

Malaria is a parasitic disease which kills millions of lives worldwide. The life cycle of the parasite revolves between a mosquito vector and a human host. Malaria is transmitted when Anopheles mosquitoes bite a human being and release hundreds of sporozoites into the bloodstream of the host. After entering into the bloodstream, parasites migrate to the liver, where they can either remain dormant or initiate an asexual multiplication cycle to produce thousands of merozoites. The newly formed merozoites attack red blood cells and further initiate the asexual replication cycle. Some of the merozoites differentiate into male and female gametocytes, which are the only parasite form that can be transmitted from humans to the mosquito vector.

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BIO 2014 Partnering: Collaboration Brings Cures to the Clinic Faster

Jun 30, 2014 3:05:38 PM / by Maria posted in drug development, Drug Discovery, innovation, partnering, research

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The Biotechnology Industry Organization (BIO) met in San Diego last week bringing together academic and industry leaders.  The goal of the meeting - to foster collaboration, promote innovation, bring cures to the clinic, and encourage economic growth. Some pretty intense objectives! How can such idealized goals be reached? There was a palpable energy around the answer: Partnering.

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