Blog | HemaCare

The Changing Landscape of Clinical Approval

Aug 27, 2019 10:04:00 AM / by Nancy Andon, MSc posted in Gene Therapy, Cell Therapy, Drug Discovery

0 Comments

HemaCare is pleased to announce the publication of our latest article [1] in the journal International Clinical Trials (ICT). The paper, entitled “The Landscape of Clinical Approval” describes how changes in the clinical drug approval process are impacting starting material suppliers, and what suppliers are doing to meet increased demands.

Read More

2018 Nobel Prize in Medicine Recognizes Immunotherapy Researchers

Jan 29, 2019 10:03:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Drug Discovery, T Cells, Immunotherapy (Immunology)

0 Comments

Advances in immunotherapy research to combat cancer has provided unprecedented treatment success due to the discoveries of two different Nobel Laureates, Dr. James P. Allison (U.S.) and Dr. Tasuku Honjo (Japan). Working independently, they each discovered immune system proteins that are important in self-tolerance and that can be harnessed to kill cancer cells. Checkpoint molecules prevent the immune system from killing the body’s own healthy cells. When checkpoint molecules are encountered by T cells, the cells bearing these molecules are spared attack. However, some cancer cells wear checkpoint molecules, acting as imposters of normal cells to evade attack by T cells.

Read More

Stem Cell Models for Alzheimer’s Disease Enable Drug Discovery and Development

Feb 3, 2016 1:00:37 PM / by Karina Palomares posted in Drug Discovery, Stem Cells

0 Comments

Scientists evaluate new treatments of Alzheimer’s disease on neurons derived from iPSCs from patients.

Alzheimer’s disease is the leading cause of dementia, and has affected approximately 48 million people worldwide. Despite decades of research, we have yet to come up with a successful treatment. One major challenge in drug development for neurological diseases is access to a clinically relevant disease model. As stated in a recent WSJ article, results from animal testing often do not predict well what will happen in humans [1].  As a result, many promising drug candidates have been removed from further development because of safety concerns or lack of efficacy.

Read More

Telomerase Inhibition Could Be a Promising Approach for Disorders of Platelets

Nov 4, 2015 1:00:45 PM / by Karina Palomares posted in Cancer, Drug Discovery, Platelets, Basic Research

0 Comments

Recent findings of a phase II clinical trial of imetelstat, a telomerase inhibitor, demonstrate that it could be a promising treatment approach for patients with essential thrombocythemia, which raises platelets to dangerous levels.

Myeloproliferative neoplasms are a group of disorders caused by an overproduction of a particular blood cell type. For example, essential thrombocythemia (ET) causes an abnormal increase in the number of platelets produced in the blood and bone marrow. Although most patients have a normal life expectancy, ET may develop into acute myeloid leukemia. Currently available drugs help manage symptoms and offer protection from heart attack or strokes, but more treatment options are necessary for those patients who are not responsive or who experienced adverse side effects.

Read More

Wasp Venom Peptide Targets Cancer Cell Membranes -- Selectively

Nov 2, 2015 1:00:04 PM / by Maria posted in Drug Discovery, natural products, Basic Research

0 Comments

Research with an insect peptide challenges the popular belief that cancer cell membranes don't make good drug targets.

Cell membranes could use a little more respect. No one doubts that the inner machinery of cells is fascinating in its complexity, but membranes themselves are often viewed as rather boring containers that are pretty much the same no matter where you look. But membranes are actually highly complex structures consisting of hundreds of different lipids and proteins, often varying in composition among cell types. Still, even many cell biologists have perhaps not realized the implications this diversity could have for drug discovery.

Read More

Subscribe Here!

Posts by Topic

see all

Recent Posts