Blog | HemaCare

Wasp Venom Peptide Targets Cancer Cell Membranes -- Selectively

Nov 2, 2015 1:00:04 PM / by Maria posted in drug discovery, natural products, research

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Research with an insect peptide challenges the popular belief that cancer cell membranes don't make good drug targets.

Cell membranes could use a little more respect. No one doubts that the inner machinery of cells is fascinating in its complexity, but membranes themselves are often viewed as rather boring containers that are pretty much the same no matter where you look. But membranes are actually highly complex structures consisting of hundreds of different lipids and proteins, often varying in composition among cell types. Still, even many cell biologists have perhaps not realized the implications this diversity could have for drug discovery.

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Novel iPSC Platform to Study Host-Pathogen Interaction

Apr 29, 2015 1:00:10 PM / by Shweta posted in drug screening, malaria, cellular reprogramming, disease-state cells, drug discovery, induced pluripotent stem cells, Innovation, stem cells

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iPSC technology helps scientists model liver-stage malaria in a dish

Malaria is a parasitic disease which kills millions of lives worldwide. The life cycle of the parasite revolves between a mosquito vector and a human host. Malaria is transmitted when Anopheles mosquitoes bite a human being and release hundreds of sporozoites into the bloodstream of the host. After entering into the bloodstream, parasites migrate to the liver, where they can either remain dormant or initiate an asexual multiplication cycle to produce thousands of merozoites. The newly formed merozoites attack red blood cells and further initiate the asexual replication cycle. Some of the merozoites differentiate into male and female gametocytes, which are the only parasite form that can be transmitted from humans to the mosquito vector.

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BIO 2014 Partnering: Collaboration Brings Cures to the Clinic Faster

Jun 30, 2014 3:05:38 PM / by Maria posted in drug development, drug discovery, innovation, partnering, research

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The Biotechnology Industry Organization (BIO) met in San Diego last week bringing together academic and industry leaders.  The goal of the meeting - to foster collaboration, promote innovation, bring cures to the clinic, and encourage economic growth. Some pretty intense objectives! How can such idealized goals be reached? There was a palpable energy around the answer: Partnering.

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4D Stem Cell Biology and the Next Generation of Regenerative Medicine

Feb 27, 2014 7:00:10 AM / by Maria posted in drug screening, gene therapy, 3D tissue culture, cell therapy, cellular reprogramming, drug discovery, Innovation, iPSCs, organ transplants, organogenesis, personalized medicine, research, stem cell therapy, stem cells, tissue engineering

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In Part I and II of this series of posts, we covered self-organization of ectodermal and endodermal tissues in 3D culture but much of the recent progress in the field of stem cell biology comes from understanding organogenesis in 3D culture in what is really more like 4 dimensions. Whereas self-organization in 3D culture uses artificial scaffolds required for cells to achieve structural formation, 4D stem cell biology involves natural development of complex tissues by following the internal agenda of the cells. Although transplantation of these self-organized tissues may be superior to conventional engineering that is not to say that the additional use of scaffolds and growth factors in tissue engineering would not improve upon the results of stem cell culture and organogenesis.

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Revolutionizing Drug Discovery with Mass-Tag Cellular Barcoding and PBMCs

Feb 6, 2014 12:00:09 PM / by Maria posted in drug screening, PBCs, antibodies, drug development, drug discovery, Innovation, mass cytometry, mass-tag cellular barcoding, MCB, Peripheral blood cells, peripheral blood mononuclear cells, phosphorylation, research

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Using peripheral blood mononuclear cells (PBMCs) with a new technique called mass-tag cellular barcoding (MCB) may change the drug discovery game as we know it.

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