Blog | HemaCare

CD34+ Stem Cells Used to Study Carbon Nanoparticle Absorption

Jan 21, 2020 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Drug Discovery, Stem Cells

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Researchers studied the potential harm of carbon nanoparticle absorption but found that lysosome encapsulation may prevent cell-damage from occurring.  

Carbon nanoparticles are very promising tools for use in the delivery of therapeutic agents in the body and for bioimaging applications to monitor drug distribution and efficacy. These particles have been successfully attached to various therapeutic agents including small drug molecules, vaccines, immunotherapeutic agents, and gene therapies. Agents can be delivered directly into cell targets without first being metabolized. However, are there adverse effects that could potentially overshadow these benefits?

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Nanotechnology for Acute Kidney Injury

Dec 30, 2019 10:06:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cell Therapy, Drug Discovery

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While there is no cure for acute kidney injury, a research team out of the University of Wisconsin-Madison may be shedding some new light on this condition.

Acute kidney injury (AKI) is characterized by a sudden decline in kidney function. This decline is marked by a significant rise in serum creatinine levels that may be accompanied by a reduction in urine output. Some cases of AKI require kidney transplantation or can lead to death. There are a number of causes of AKI, including injury from gadolinium-based contrast agents (nephrogenic systemic fibrosis), rhabdomyolysis, low blood volume, and vasculitis.

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NK Cells Used to Find Cause of Fatal Hepatitis A Cases

Nov 26, 2019 10:03:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Drug Discovery, NK Cells

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A drug used to treat acetaminophen hepatotoxicity may give hope to an effective treatment for FVH caused by liver-impairing viruses, including hepatitis A.

Fulminant viral hepatitis (FVH) is a form of acute liver failure caused by a virus and characterized by severe impairment of liver function. Primarily, children and young adults are affected, and the condition is usually fatal unless liver transplantation is implemented early enough. FVH tends to occur in people who are healthy and without any history of previous liver disease and progresses rapidly leading to encephalopathy and death. Given the treatment challenges and lack of a full understanding of how FVH develops, a group of scientists from Rockefeller University in New York analyzed the DNA of an 11-year-old girl who died from FVH.

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The Changing Landscape of Clinical Approval

Aug 27, 2019 10:04:00 AM / by Nancy Andon, MSc posted in Gene Therapy, Cell Therapy, Drug Discovery

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HemaCare is pleased to announce the publication of our latest article [1] in the journal International Clinical Trials (ICT). The paper, entitled “The Landscape of Clinical Approval” describes how changes in the clinical drug approval process are impacting starting material suppliers, and what suppliers are doing to meet increased demands.

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2018 Nobel Prize in Medicine Recognizes Immunotherapy Researchers

Jan 29, 2019 10:03:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Drug Discovery, T Cells, Immunotherapy (Immunology)

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Advances in immunotherapy research to combat cancer has provided unprecedented treatment success due to the discoveries of two different Nobel Laureates, Dr. James P. Allison (U.S.) and Dr. Tasuku Honjo (Japan). Working independently, they each discovered immune system proteins that are important in self-tolerance and that can be harnessed to kill cancer cells. Checkpoint molecules prevent the immune system from killing the body’s own healthy cells. When checkpoint molecules are encountered by T cells, the cells bearing these molecules are spared attack. However, some cancer cells wear checkpoint molecules, acting as imposters of normal cells to evade attack by T cells.

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