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Stem Cell Technology Helps to Build a Miniature Beating Heart

Aug 19, 2015 1:00:02 PM / by Shweta posted in drug screening, Assay Development, induced pluripotent stem cells, Innovation, Regenerative Medicine, research, Stem Cells, tissue engineering

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Scientists created a tiny heart in the lab using stem cells

Stem cell research is continuously evolving and will likely become more and more effective in the near future. Researchers are continuously making efforts to grow stem cell-based organs in the lab using 3D modeling. Developing patient-specific organs to replenish degenerated organs or to screen drugs is a Holy Grail for the revolutionary tissue engineering field.

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Stem Cell Test to Determine Cytokine Release Syndrome Ahead of Time

Jun 22, 2015 1:00:31 PM / by Shweta posted in drug screening, Innovation, PBMC, research, Stem Cells, T lymphocytes, white blood cells, Whole Blood

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Another potential application of human stem cells is to recognize side effects of drugs

Biological therapy is a form of treatment that uses biological materials such as antibodies and stem cells. Several biological therapies, including monoclonal antibodies, are now well established as part of the treatment for many diseases such as cancer, transplant rejection, autoimmune disorders, and infections. Personalized medicine is now a key emerging technology in drug development. However, they can cause adverse side effects in humans. Therefore, biologic therapies require the use of human tissue-based bioassays to measures the efficacy and safety of the drug.

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Novel iPSC Platform to Study Host-Pathogen Interaction

Apr 29, 2015 1:00:10 PM / by Shweta posted in drug screening, malaria, cellular reprogramming, disease-state cells, Drug Discovery, induced pluripotent stem cells, Innovation, Stem Cells

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iPSC technology helps scientists model liver-stage malaria in a dish

Malaria is a parasitic disease which kills millions of lives worldwide. The life cycle of the parasite revolves between a mosquito vector and a human host. Malaria is transmitted when Anopheles mosquitoes bite a human being and release hundreds of sporozoites into the bloodstream of the host. After entering into the bloodstream, parasites migrate to the liver, where they can either remain dormant or initiate an asexual multiplication cycle to produce thousands of merozoites. The newly formed merozoites attack red blood cells and further initiate the asexual replication cycle. Some of the merozoites differentiate into male and female gametocytes, which are the only parasite form that can be transmitted from humans to the mosquito vector.

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3D Stem Cell Models for In Vitro Skin Studies

Jul 16, 2014 1:00:14 PM / by Maria posted in drug screening, animal testing, drug development, Independent validation, induced pluripotent stem cells, mesenchymal, research, Stem Cells

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It doesn’t get much trendier these days than either 3-dimentional (3D) or stem cells. Put the two together and you have cooler-than-cool 3D stem cell models, a topic pregnant with possibilities.  

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4D Stem Cell Biology and the Next Generation of Regenerative Medicine

Feb 27, 2014 7:00:10 AM / by Maria posted in drug screening, Gene Therapy, Cell Therapy, cellular reprogramming, Drug Discovery, Innovation, iPSCs, organ transplants, organogenesis, personalized medicine, research, stem cell therapy, Stem Cells, tissue engineering

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In Part I and II of this series of posts, we covered self-organization of ectodermal and endodermal tissues in 3D culture but much of the recent progress in the field of stem cell biology comes from understanding organogenesis in 3D culture in what is really more like 4 dimensions. Whereas self-organization in 3D culture uses artificial scaffolds required for cells to achieve structural formation, 4D stem cell biology involves natural development of complex tissues by following the internal agenda of the cells. Although transplantation of these self-organized tissues may be superior to conventional engineering that is not to say that the additional use of scaffolds and growth factors in tissue engineering would not improve upon the results of stem cell culture and organogenesis.

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