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Stem Cell Technology Helps to Build a Miniature Beating Heart

Aug 19, 2015 1:00:02 PM / by Shweta posted in drug screening, Assay Development, iPSCs, Regenerative Medicine, Stem Cells, tissue engineering, Basic Research

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Scientists created a tiny heart in the lab using stem cells

Stem cell research is continuously evolving and will likely become more and more effective in the near future. Researchers are continuously making efforts to grow stem cell-based organs in the lab using 3D modeling. Developing patient-specific organs to replenish degenerated organs or to screen drugs is a Holy Grail for the revolutionary tissue engineering field.

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Stem Cell Test to Determine Cytokine Release Syndrome Ahead of Time

Jun 22, 2015 1:00:31 PM / by Shweta posted in drug screening, PBMCs, Stem Cells, T lymphocytes, white blood cells, Whole Blood, Basic Research

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Another potential application of human stem cells is to recognize side effects of drugs

Biological therapy is a form of treatment that uses biological materials such as antibodies and stem cells. Several biological therapies, including monoclonal antibodies, are now well established as part of the treatment for many diseases such as cancer, transplant rejection, autoimmune disorders, and infections. Personalized medicine is now a key emerging technology in drug development. However, they can cause adverse side effects in humans. Therefore, biologic therapies require the use of human tissue-based bioassays to measures the efficacy and safety of the drug.

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Novel iPSC Platform to Study Host-Pathogen Interaction

Apr 29, 2015 1:00:10 PM / by Shweta posted in drug screening, cellular reprogramming, disease-state cells, Drug Discovery, iPSCs, Stem Cells, Infectious Disease

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iPSC technology helps scientists model liver-stage malaria in a dish

Malaria is a parasitic disease which kills millions of lives worldwide. The life cycle of the parasite revolves between a mosquito vector and a human host. Malaria is transmitted when Anopheles mosquitoes bite a human being and release hundreds of sporozoites into the bloodstream of the host. After entering into the bloodstream, parasites migrate to the liver, where they can either remain dormant or initiate an asexual multiplication cycle to produce thousands of merozoites. The newly formed merozoites attack red blood cells and further initiate the asexual replication cycle. Some of the merozoites differentiate into male and female gametocytes, which are the only parasite form that can be transmitted from humans to the mosquito vector.

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Drug Screening in Healthy and Diseased PBMCs

Jan 22, 2014 2:32:37 PM / by Maria posted in drug screening, PBCs, proliferation, apoptosis, Drug Discovery, infection, Inflammation, migration, PBMCs, Peripheral blood cells, viability, Basic Research

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Peripheral Blood Mononuclear Cells (PBMCs) can be used in drug screening.  In Part I from this series, we discussed how they can be used to assay drug activity including effects on proliferation, viability, apoptosis, inflammation, and migration in healthy and disease cell models.  There are related assays available to measure the effects of drug treatment and, especially for researchers that prefer to use human samples, peripheral blood mononuclear cells are often the cells of choice (PBMCs) are often the cells of choice.  The advantages of using human cells initially are immense.

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Peripheral Blood Mononuclear Cells in Drug Discovery and Development

Jan 14, 2014 7:00:10 AM / by Maria posted in drug screening, Drug Discovery, PBMCs, Peripheral blood cells, Basic Research

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Use of human samples including peripheral blood mononuclear cells (PBMCs) in drug discovery is critical for increasing the chances of success for a small molecule screen hit. This is the first in a four part series on peripheral blood mononuclear cells and their use in drug discovery.

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