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"Extraordinary" CAR T Cells Eliminate Cancer After Stem Cell Transplant

Mar 21, 2016 1:00:05 PM / by Maria posted in Bone marrow, donor lymphocyte infusion, graft versus host disease, research, stem cell transplantation

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Donor-derived lymphocytes attack a patient's cancer -- but may attack the patient as well. Donor CAR T cells, on the other hand, brought remissions without this troubling complication.

CAR T cells continue to make waves: At the latest annual meeting of the American Association for the Advancement of Science, it was announced that CAR T cells, in which T cells from a patient are genetically reprogrammed to target cancer cells, removed all traces of cancer in the bone marrow of 27 out of 29 acute lymphoblastic leukemia patients. Nineteen of 30 individuals with non-Hodgkin lymphoma also responded in the form of partial or complete responses. The cumulative successes found in CAR T cell studies have labeled them "extraordinary."[1]

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When It's Really Bad: Bone Marrow Transplant for Crohn's Disease?

Oct 26, 2015 1:00:00 PM / by Maria posted in Bone marrow, bone marrow transplantation, chemotherapy, graft versus host disease, research

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Some patients with Crohn's disease don't respond to treatment, and life is extremely impaired. Do drastic times call for drastic measures?

Millions of people worldwide have Crohn's disease, a gastrointestinal disorder that causes diarrhea, cramps, and fatigue, among other symptoms throughout the body. The exact cause of Crohn's disease remains a mystery, but scientists believe that patients are genetically predisposed to Crohn's disease, and in particular, a patient's immune system is in play.

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