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Targeting T Cells to Treat IBD

Sep 4, 2018 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Autoimmune Disorders, T Cells, Helper T Cells


Recent research looks into the relationship between T helper cells and the autoimmune conditions of inflammatory bowel disease (IBD).

Crohn’s disease and ulcerative colitis are two forms of inflammatory bowel disease (IBD) caused by an immune dysfunction. People with IBD can experience diarrhea, rectal bleeding, constipation, abdominal pain and cramping, fatigue, loss of appetite, and weight loss. Dysregulated responses of a subset of CD4 T cells (T helper cells) are associated with autoimmune and chronic inflammatory conditions and may induce and maintain intestinal inflammation, but the mechanism is not fully understood. The primary cytokine secreted by T helper cells of the intestinal mucosa of people with IBD is interferon (IFN)-gamma. Recent research was conducted to better understand the role of IFN-producing CD4 T cells in the initiation and maintenance of IBD.

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PBMCs and Psoriasis Treatments

Jun 18, 2018 10:11:00 AM / by Stacy Matthews Branch, DVM, PhD posted in B Cells, PBMCs, Helper T Cells, immune cells


Scientists examined the peripheral blood mononuclear cell (PBMC) profiles of patients with and without psoriasis, including those that both responded to classic treatments and didn’t respond. They then analyzed the profile of those immune cell types. Here are the results of that study.

There are often differences among patient populations for a given disease in how effective a treatment provides medical relief. An important part of personalized medicine is identifying patients that are not likely to respond to a treatment regimen for a specific disease or condition. Doing this can limit the loss of time and resources in using ineffective treatments and can allow the use of personalized treatments in these populations.

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Dual Role of IL-2R Protein in the Immune System: Fights Both Inflammation and Cancer

Dec 7, 2016 12:00:15 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Cytotoxic T Cells, Inflammation, Helper T Cells, Basic Research


Regulatory T cells (Tregs) are immune cells that function to regulate the immune system in order to prevent autoimmune disease. They do this by sustaining immune tolerance to the body’s own cells and antigens. Tregs are known to have interleukin 2 receptors (IL-2R), and their functions depend on interleukin 2 (IL-2), a cytokine that is released by T helper cells and act on cytotoxic T cells.

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T Cell Stimulatory vs. Polarizing Capacity of Human Primary Blood Dendritic Cell Subsets

Oct 11, 2016 10:08:38 AM / by Stacy Matthews Branch, DVM, PhD posted in Dendritic Cells, Helper T Cells, Immunotherapy (Immunology)


Dendritic cells are an important component of the immune system. These cells are responsible for priming T cells for attack on antigens (disease causing agents). They are antigen-presenting cells; that is, they process and prepare the antigens for recognition and action by T cells. Results of studies using primary blood dendritic cells show that they have promise in cancer immunotherapy.

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