Dual-Affinity Re-Targeting (DART) molecules incorporating Env-binding specificities with a CD3-binding specificity potently and selectively kill HIV-infected cells.
We recently discussed how new research indicates that activation of latent HIV is a necessary step for eradication of disease. Most antiretroviral drugs only target actively replicating HIV. If antiretroviral therapy is stopped, latent HIV returns to an active form, resulting in a rebound of viral load. Thus, activation of latent HIV to render it susceptible to antiretroviral drugs is a potential strategy to completely eliminate HIV reservoirs.