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Peptide Pools for Immune Monitoring? PBMC from HemaCare Help Argue the Case

Jun 29, 2016 1:00:53 PM / by Maria posted in antigens, CD8+ T cells, HLA alleles, research


How often do predicted peptides actually get recognized by CD8+ cells? The surprising answer was provided in part by HemaCare's PBMC.

We all have our type -- HLA type, that is. Each human has up to six different HLA Class 1 molecules, from out of more than 100  MHC/HLA Class I alleles in existence to "choose" from. These allelic HLA variants are unique in their peptide-binding specificity, meaning that antigen recognition by CD8+ T cells depends on the alleles that you have. "Peptide recognition by CD8 cells is therefore highly variable among individuals of an outbred population, as variable as the HLA system itself." [1]

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