How often do predicted peptides actually get recognized by CD8+ cells? The surprising answer was provided in part by HemaCare's PBMC.
We all have our type -- HLA type, that is. Each human has up to six different HLA Class 1 molecules, from out of more than 100 MHC/HLA Class I alleles in existence to "choose" from. These allelic HLA variants are unique in their peptide-binding specificity, meaning that antigen recognition by CD8+ T cells depends on the alleles that you have. "Peptide recognition by CD8 cells is therefore highly variable among individuals of an outbred population, as variable as the HLA system itself."