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Hematopoietic Stem Cells Require a Highly Regulated Protein Synthesis Machinery

Apr 30, 2014 1:00:09 PM / by Maria posted in cancer, hematopoietic stem cells, HSCs, Innovation, protein synthesis, research, stem cells

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Rate of Protein Synthesis can Influence Hematopoietic Stem Cells Function

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Engineering Hematopoietic Stem Cells for a One-Two Punch of Cancer Immunotherapy

Mar 26, 2014 6:16:13 AM / by Maria posted in PBCs, cancer, Cancer Immunology, cancer immunotherapy, cell therapy, chemotherapy, drug development, hematopoietic stem cells, HSCs, immunotherapy, Innovation, leukemia, lymphoma, Peripheral blood cells, research, stem cell therapy, stem cells, T cells

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In Part I of this series we introduced T cell based immunotherapy and in Part II we discussed how chimeric antigen receptors (CARs) expressing T cells can be even more potent. In Part III below, we expand this concept further by covering hematopoetic stem cells and additional ways they can be engineered for promising immunotherapy of cancer and leukemia.

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CAR-Expressing T Cells: Driving the Express Track to Cancer Immunity

Mar 19, 2014 6:10:31 AM / by Maria posted in cancer, Cancer Immunology, cancer immunotherapy, cell therapy, chemotherapy, drug development, hematopoietic stem cells, HSCs, immunotherapy, Innovation, leukemia, lymphoma, research, T cells, T lymphocytes, tumor, tumor cells

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In the first part of this series we introduced the concept of cell-based immunotherapy with T cell transplants. Next, we describe an even more potent approach to cancer treatment with T cells that are engineered to express anti-tumor molecules or cell surface tumor-identifying killer receptors. The latter of which are called chimeric antigen receptors, or CARs.

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Sex Differences Affect Stem Cell Function in Blood

Feb 18, 2014 12:00:06 AM / by Maria posted in cell therapy, hematopoietic stem cells, HSCs, stem cells

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Cell therapy is thought to be the ultimate treatment for degenerative disease and cancer. Stem cells or progenitor cell transplantation will replace those damaged cells or tissue, because stem cells are immature, un-differentiated cells that have potential to produce a variety of cells in our body. The majority of stem cell therapy options (embryonic stem cell, patient specific induced pluripotent stem cells, neural stem cells and mesenchymal stem cells) are still in animal experimental or pre-clinical stage. Currently, only hematopoietic stem cells (HSCs) are used in the clinic to treat patients with cancer, blood or immune defects. High quality hematopoietic stem cells can be purchase from HemaCare.

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Bone Marrow: a Major Player in Immune Response to Infection

Feb 10, 2014 12:00:23 PM / by Maria posted in Bone marrow, hematopoietic stem cells, HSCs, immunology, stem cells

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The immune system undergoes dynamic changes to counteract infection with pathogens or inflammation.  This includes the bone marrow, whose diverse cell population is profoundly altered in proportion.

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