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Human B-1 and B-2 B Cells Develop from Common Progenitors

Dec 12, 2016 12:45:21 PM / by Stacy Matthews Branch, DVM, PhD posted in cd 34 stem cells, human b-1 cells, human b-2 cells, research, stem cell research, stem cells

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There are two broad populations of B cells, B-1 and B-2. B-1 cells are the primary B cell during fetal and neonatal development. These cells can self-renew and localize mainly in the peritoneal and pleural cavities. B-1 cells produce the majority of “natural” antibodies, immunoglobulin (Ig) M and IgA. Natural antibodies exist in the blood of healthy individuals before immunization, are the first line of defense against pathogens (disease-causing antigens), and they also influence T cell expansion.

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