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Bone-forming cells enhance production of human cord blood cells

Oct 26, 2016 1:28:46 PM / by Stacy Matthews Branch, DVM, PhD posted in blood-forming, bone-forming cells, Bone marrow, human cord blood stem cells, stem cells

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Human cord blood is a critical source of cells used to treat blood disorders. However, this source contains low numbers of cells that make successful transplants more difficult. The bone marrow of adults contain blood-forming stem cells that are self-renewing, can grow well, and can become different types of mature blood cells. Osteoblasts (bone-forming cells) are involved in the production of hematopoietic (blood-forming) stem and progenitor cells (HSPCs). Studies have shown that osteoblasts release extracellular vesicles (EVs), small structures within cells that contain various molecules and factors for various cellular functions. The EVs from osteoblasts play a role in maintaining a source of HSPCs needed for hematopoiesis (blood cell formation).

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New Research Shows Hope for Cancer Patients

Oct 12, 2016 1:00:52 AM / by Stacy Matthews Branch, DVM, PhD posted in Bone marrow, bone marrow stem cells, human cord blood stem cells

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F or cancers such as leukemia (cancer of the white blood cells), chemotherapy followed by stem-cell transplantation to repopulate with healthy cells is the treatment of choice. There are various sources of stem cells including bone marrow , circulating blood, and umbilical cord blood. Researchers reviewed hundreds of cases of leukemia as well as other blood disorders. They found that those patients who received stem cells from human cord blood , had survival rates that were similar to or higher than those who received other types of stem cell transplants.
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