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PBMCs and Psoriasis Treatments

Jun 18, 2018 10:11:00 AM / by Stacy Matthews Branch, DVM, PhD posted in PBMCs, PBMC, peripheral blood mononuclear cells, B cells, T helper cells, immune cells

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Scientists examined the peripheral blood mononuclear cell (PBMC) profiles of patients with and without psoriasis, including those that both responded to classic treatments and didn’t respond. They then analyzed the profile of those immune cell types. Here are the results of that study.

There are often differences among patient populations for a given disease in how effective a treatment provides medical relief. An important part of personalized medicine is identifying patients that are not likely to respond to a treatment regimen for a specific disease or condition. Doing this can limit the loss of time and resources in using ineffective treatments and can allow the use of personalized treatments in these populations.

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Stem Cell-Like Function of Adult Immune Cells Stimulate Healing

Apr 9, 2018 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in stem cells, macrophages, immune cells

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New research suggests that wound fluid induced macrophage clustering shows improved healing.

Tissue damage is repaired by the proliferation of normal cells, tissue stem cell maturation, and scar formation. However, the inflammation associated with tissue damage or injury promotes cell plasticity as part of the tissue repair process. Fibroblasts that are critical for wound healing are mesenchymal cells that are actually derived from myeloid cells such as macrophages. Macrophages are immune cells that are the first line of defense against pathogens. They are also important in wound healing and inflammatory processes.

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