Melanoma is the most serious form of skin cancer and more likely to grow and metastasize. It has a high response rate to checkpoint inhibitor therapy compared to other cancers; however, about 60% of patients treated do not respond well or relapse. Immune checkpoints are proteins expressed on T cells and function to ensure self-tolerance, but they are also used by tumor cells to limit anti-tumor immune function.
“Kiss-and-run” approach helps researchers observe interaction between dendritic cells and T cells.
The normal biological processes needed for living beings to develop, grow, and function involve interactions between a diversity of cell types. Targeting these cellular interactions can enhance current cell-based immunotherapy and regenerative medicine, as well as provide the basis for new ones. Studying the mechanisms of these interactions is necessary in order to understand the means by which they affect cell signaling, immunity, growth and development, and more.
Advances in immunotherapy research to combat cancer has provided unprecedented treatment success due to the discoveries of two different Nobel Laureates, Dr. James P. Allison (U.S.) and Dr. Tasuku Honjo (Japan). Working independently, they each discovered immune system proteins that are important in self-tolerance and that can be harnessed to kill cancer cells. Checkpoint molecules prevent the immune system from killing the body’s own healthy cells. When checkpoint molecules are encountered by T cells, the cells bearing these molecules are spared attack. However, some cancer cells wear checkpoint molecules, acting as imposters of normal cells to evade attack by T cells.
Global biotechnology company Immunospot cites using B cells isolated from HemaCare-sourced peripheral blood mononuclear cells (PBMC)  for their studies on post-cryopreservation functionality.
Expectations are high that emerging field of cell therapy will be able to deliver breakthrough treatments or cures for many diseases, including cancer. One of the most powerful facets of this new medical field is the concept of immunotherapy--using the body’s own immune cells to specifically target disease. Immune cell function is at the heart of this concept, so keeping immune cells fully operational is crucially important. In this recent study published in the journal Cells, biopharmaceutical scientists aim to investigate B cell functionality following cryopreservation.
2018 has flown by, and 2019 is just around the corner! As the New Year approaches, it’s good to look back at just how much has been accomplished in the field of medicine, and wonder what the future holds. As is our tradition at this time of year, we are pleased to present HemaCare’s 10 most popular blogs of the year, and the advances in healthcare that they represent. Enjoy the countdown!