Blog | HemaCare

A paper published in the journal Blood cites the use of HemaCare-sourced peripheral blood mononuclear cells (PBMCs) to test a murine model of a new antibody-based cancer immunotherapy.

Multiple myeloma (MM) is a life-threatening disease that accounts for 10-15% of all blood-based cancers. The disease occurs when a specific group of white blood cells, known as plasma cells, become malignant. T cell therapy has shown some promise in treating the disease on a temporary basis, but with very few cancer-specific targets identified, MM remains incurable.

A recent Phase I trial studying the effect of TIL therapy on lung cancer shows promising results for long-term patient remission.

Tumor-infiltrating lymphocytes (TILs) are T-cells that infiltrate solid tumors to attack tumor antigens. Still, the tumor microenvironment inhibits T-cell growth leading to low numbers of the cells and insufficient immune response. Checkpoint proteins on tumor surfaces, such as PD-1, can also further inhibit T-cell response in tumors. However, in the case of melanoma, scientists have been able to achieve a complete remission with TILs that can last over a decade.

While the world waits for a coronavirus vaccine, scientists are looking to viral and cell therapy treatments for a solution.

Since China began reporting COVID-19 cases to the World Health Organization (WHO), the novel virus has since spread globally. With the declaration of COVID-19 as a global pandemic, announcements about efforts to develop a coronavirus vaccine are ongoing and constant.

Researchers are studying the importance of white adipose tissue and its role in storing memory T cells.

The idea that if you don’t eat enough, you’ll get sick may be true in some ways, but there is new information available revealing that the immune system may have a strategy to keep fighting infectious agents even when food is scarce.

Scientists in New York studying allergic disease have just published work citing the use of HemaCare-sourced bone marrow mononuclear cells for their research into the mechanisms of immunological memory.

The immune system is a wonderfully complex assembly of interacting cells and tissues that protect us from disease. To function properly, the cells within this system must detect and remember a wide variety of triggering agents.