Blog | HemaCare

HIV Cell Therapy in Development

Oct 8, 2018 10:13:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Leukopak, T Cells, Infectious Disease

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Combining various treatment approaches is seen as a viable, more powerful means to achieve HIV cure states.

From the time that HIV-related illness and death was first realized in the 1980s until now, efforts to fully understand HIV infection and pathogenesis have been ongoing along with massive research efforts to discover a cure or means to control the spread of the virus. The newest antiviral therapies have made an extraordinary impact on the control of disease progression; however, these do not cure HIV infection and the viral activity returns shortly after antiviral dosing stops. Approaches to achieve HIV immunity are heavily studied, including developing means to provide HIV immunity in T cells and conferring HIV-resistance via gene editing. However, combining various approaches is seen as a viable, more powerful means to achieve HIV control or even a cure.

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Can Stem Cells Treat Lyme Disease?

Sep 10, 2018 10:12:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Stem Cell Therapy, Stem Cells, Infectious Disease

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Because many people with Lyme disease do not fully recover with antibiotics alone, many are seeking stem cell treatments as an option.

Lyme disease is transmitted by the bite of blacklegged ticks (deer tick, Ixodes scapularis) infected with Borrelia burgdorferi bacteria. A number of debilitating and long-lasting symptoms can include the development of a distinctive skin rash (erythema migrans), fever, fatigue, muscle pain, and headaches. Due to the nonspecific and diverse symptoms, Lyme disease is often misdiagnosed and can progress to serious conditions of the heart, nervous, and musculoskeletal systems.

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Therapeutic Hope for Patients with Chronic Viral Hepatitis

Aug 23, 2017 3:09:11 PM / by Stacy Matthews Branch, DVM, PhD posted in Cytotoxic T Cells, Infectious Disease

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Hepatitis is an inflammation of the liver caused most commonly by hepatitis viruses. Cytotoxic T cells have essential roles in patients with viral hepatitis. Virus-specific cytotoxic T cells can recognize viral antigens of infected liver cells in collaboration with T helper cells. Despite this function in viral hepatitis, the cytotoxic T cell response is nearly undetectable in patients with chronic hepatitis B or C infections.

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Virion-Associated Vpr Restores the Ability of HIV-1 to Infect Dendritic Cells

May 9, 2017 10:20:59 AM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, Dendritic Cells, Infectious Disease

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The HIV-1 virus produces various proteins needed for infection and replication in human cells. Some of these are accessory proteins that mainly help the HIV-1 virus to evade the immune system defenses and to overcome factors that function to restrict or inhibit infection. One protein that may function in this way is the Vpr protein, which is a virion (infective virus form)-associated protein.

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PBMC Estrogen Receptor α Gene Expression May Predict Response to Interferon Therapy in Patients with Chronic Hepatitis B Infection

Jan 16, 2017 12:00:23 AM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, PBMCs, pegylated interferon, Infectious Disease, Basic Research

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Hepatitis B is a viral infection that can cause liver damage. Most healthy adults that contract the acute infection can be symptom free and clear the virus. Some people cannot clear the virus after several months, developing the chronic form of the infection. Pegylated interferon is a slow-release form of an immune molecule that has been shown to inhibit virus replication and limit liver damage.

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