Many people have donated blood in their lifetime. This blood is not only used for transfusions, but to provide blood components to treat a number of diseases and to conduct research geared to develop new diagnostic and treatment strategies. To obtain specific blood components, the technique of apheresis is used. This procedure is the means to separate blood into its various components so that the desired one is removed. Then, the rest of the components are placed back into the donor’s circulation.
For many years, cancer therapy has been tackled with a more or less universal approach. The drawback of this approach to therapy is the wide range of different responses to a given therapy. The concept of personalized medicine, tailoring treatment to a patient’s specific characteristics, has been envisioned and desired for many years. It is now being studied and implemented to increase successful responses to therapy, including cancer therapy.
Scientists find that NOD-2 derived dendritic cells have superior bactericidal activity.
Intracellular bacterial infections, such as tuberculosis, Listeria or E. coli, are serious health threats. All can be deadly if our immune system fails to contain and get rid of the infection promptly. Scientists have just found a way to make dendritic cells better at restricting the growth of intracellular bacteria, particularly tuberculosis.
A new strategy significantly increases the efficacy of dendritic cell immunotherapy against high grade glioma, a severe type of brain cancer. The key: pre-exposing the therapy to glioma cells undergoing immunogenic cell death.
High grade glioma (HGG) is a malignant brain cancer that is characterized by tumorous growth of glial cells, non-neural cells surrounding the neurons of the central and peripheral nervous system. HGG is accompanied by a heartbreakingly poor prognosis and the current lack of a cure. Hundreds of children are diagnosed every year with HGG in Europe and North America.
The following infographic discusses the differences between primary cells and cell lines.
Historically, cell lines have been useful research tools. However, they are subject to a number of inherent risks due to their altered or engineered nature, creating an "artificial cell-based system".