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A Bioprinted Liver Model Featuring Induced Pluripotent Stem Cells

Apr 18, 2016 1:00:33 PM / by Steffen Porwollik posted in bioprinting, 3D tissue culture, cancer, Innovation, iPSCs, liver cirrhosis, liver disease, research, stem cells

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Scientists develop a 3D liver tissue model that better resembles a working organ – by bioprinting layers of three cell types that include hepatic progenitors obtained from induced pluripotent stem cells.

The human liver is an astoundingly large organ with a very complex set of tasks. It weighs in at about 3lbs and filters the blood that comes from the digestive tract, detoxifies chemicals, metabolizes drugs and makes important proteins that help with blood clotting. Its health is of vital importance, quite literally. Sadly, liver disease is on the rise. There are more than 100 different kinds of liver maladies, including viral forms such as hepatitis A, B and C, bacterial diseases, diseases caused by autoimmune disorders, and cancer. Shockingly, fatty liver disease and its chronic conclusion, cirrhosis, both alcohol-related and non-alcohol-related, are found in up to 25% of Americans today.

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Stem Cell Models for Alzheimer’s Disease Enable Drug Discovery and Development

Feb 3, 2016 1:00:37 PM / by Karina Palomares posted in Alzheimer's disease, iPSCs, stem cells

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Scientists evaluate new treatments of Alzheimer’s disease on neurons derived from iPSCs from patients.

Alzheimer’s disease is the leading cause of dementia, and has affected approximately 48 million people worldwide. Despite decades of research, we have yet to come up with a successful treatment. One major challenge in drug development for neurological diseases is access to a clinically relevant disease model. As stated in a recent WSJ article, results from animal testing often do not predict well what will happen in humans [1].  As a result, many promising drug candidates have been removed from further development because of safety concerns or lack of efficacy.

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Stem Cells Peel Mysteries of Autism

Sep 30, 2015 1:00:42 PM / by Maria posted in autism, iPSCs, neuronal development, research, stem cells

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Using stem cells, researchers discern patterns to this puzzling disorder

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Exciting Discovery Leads to Generation of New Class of Pluripotent Stem Cells

Mar 18, 2015 1:00:39 PM / by Shweta posted in cell therapy, cellular reprogramming, induced pluripotent stem cells, iPSCs, research, stem cells

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Researchers produced a new class of pluripotent stem cells using cellular reprogramming

The remarkable discovery of induced pluripotent stem cell technology by Japanese researcher Shinya Yamanaka has revolutionized the field of stem cell biology. Yamanaka and his group showed that somatic cells can be reprogrammed by transferring their nuclear material into oocytes or by fusion with embryonic stem (ES) cells, indicating that unfertilized eggs and ES cells contain factors that can confer totipotency or pluripotency to somatic cells [1]. This cutting-edge finding has since advanced stem cell research. The creation of patient-specific disease cell lines can help scientists model a disease in a petri dish for the study and possible treatment of degenerative disorders with autologous cells.

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Stem Cell Research Brings Hope For Hair Loss

Mar 4, 2015 1:00:28 PM / by Shweta posted in cell therapy, induced pluripotent stem cells, Innovation, iPSCs, regenerative medicine, research, stem cell research, Stem Cell Therapy, stem cell transplantation

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Scientists at Sanford-Burnham Medical Research Institute have developed an efficient protocol to grow hair follicles from human pluripotent stem cells

Researchers at Sanford-Burnham Medical Research Institute, La Jolla, California have used human pluripotent stem cells to restore hair growth. The study has generated hope for millions of men and women experiencing baldness. The American Hair Loss Association claims that by the age of 35, around two-thirds of American men will experience some hair loss, and by the age of fifty approximately 85% of men have significantly thinning hair. But women are also affected, making up 40% of all hair loss sufferers. Baldness is a progressive and irreversible condition, which may affect social relationships and self-confidence. The condition has been difficult to treat.

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