Using stem cells, researchers discern patterns to this puzzling disorder
Scientists used humanized mice to demonstrate the differential immunogenicity of cells derived from autologous induced pluripotent stem cells (iPSCs)
The discovery of induced pluripotent stem cells (iPSCs) has been considered as one of the groundbreaking findings in the history of life science research. This innovation has changed the direction of stem cell research around the world and may represent an ideal cell source for future regenerative therapies. But the fact that iPSCs are derived from an individual’s own body does not eliminate the possibility of immune rejection completely. A research group at UC San Diego previously reported that abnormal gene expression may elicit the immune system to reject certain cells derived from iPSCs.
Scientists created a tiny heart in the lab using stem cells
Stem cell research is continuously evolving and will likely become more and more effective in the near future. Researchers are continuously making efforts to grow stem cell-based organs in the lab using 3D modeling. Developing patient-specific organs to replenish degenerated organs or to screen drugs is a Holy Grail for the revolutionary tissue engineering field.
Scientists have developed a method to track transplanted stem cells in the brain
Stem cell therapies have emerged as promising therapeutic options for treating many degenerative diseases including neurodegenerative diseases. The neurodegenerative diseases are characterized by the progressive degeneration of neurons. Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are the most prevalent examples of neurodegenerative disorders. A variety of stem cells, including pluripotent embryonic stem cells, multipotent adult stem cells and induced pluripotent stem cells (iPSCs) have been utilized as therapeutic agents to treat many neurological disorders.
iPSC technology helps scientists model liver-stage malaria in a dish
Malaria is a parasitic disease which kills millions of lives worldwide. The life cycle of the parasite revolves between a mosquito vector and a human host. Malaria is transmitted when Anopheles mosquitoes bite a human being and release hundreds of sporozoites into the bloodstream of the host. After entering into the bloodstream, parasites migrate to the liver, where they can either remain dormant or initiate an asexual multiplication cycle to produce thousands of merozoites. The newly formed merozoites attack red blood cells and further initiate the asexual replication cycle. Some of the merozoites differentiate into male and female gametocytes, which are the only parasite form that can be transmitted from humans to the mosquito vector.